Data associated with the publication: State Medicaid policies on mobile crisis teams: a national policy mapping analysis

This dataset accompanies a national policy mapping study of Medicaid guidance for mobile crisis team (MCT) services across all 50 states and the District of Columbia. It includes PDFs of state Medicaid documents (provider manuals, waivers, toolkits), as well as Excel files that code the presence or absence of 53 policy features across 15 domains. The study identifies patterns and gaps in clarity and structure of Medicaid guidance for behavioral health crisis response. Supplemental materials include coding reliability statistics and narrative descriptions. For Nevada and West Virginia, publicly available documents were not available and are not included in this collection

Data associated with the publication: Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility

SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through its GAP enzymatic activity, SYNGAP1 plays an important structural role through its interaction with post-synaptic density proteins. Here, we reveal that intrinsic excitability deficits and seizure phenotypes in heterozygous Syngap1 knockout (KO) mice are differentially dependent on Syngap1 GAP activity. Cortical excitatory neurons in heterozygous KO mice displayed reduced intrinsic excitability, including lower input resistance, and increased rheobase, a phenotype recapitulated in GAP-deficient Syngap1 mutants. However, seizure severity and susceptibility to pentylenetetrazol (PTZ)-induced seizures were significantly elevated in heterozygous KO mice but unaffected in GAP-deficient mutants, implicating the structural rather than enzymatic role of Syngap1 in seizure regulation. These findings highlight the complex interplay between SYNGAP1 structural and catalytic functions in neuronal physiology and disease. Here we deposit files including Axon binary files (abf), and Excel spreadsheets (xlsx) to supplement the published analysis.</p

Code associated with the publication: Low levels of H5N1 HA and NA antibodies in the human population are boosted by seasonal A/H1N1 infection but not by A/H3N2 infection or influenza vaccination

An increase in the number of human cases of influenza A/H5N1 infection in the US has raised concerns about the pandemic potential of the virus. Preexisting population immunity is a key determinant for risk assessment and pandemic potential for influenza virus. Antibody responses against the bovine A/H5N1 hemagglutinin (HA) and neuraminidase (NA) proteins were measured among a population of influenza-vaccinated or influenza-infected individuals. Modest titers of bovine A/H5N1 HA-binding antibodies and low to undetectable neutralizing antibody responses were detected in a cohort of 73 individuals. Conversely, bovine A/H5N1 NA binding and neuraminidase-inhibiting antibody responses were comparable to those against a human A/H1N1 NA at baseline. Seasonal influenza vaccination failed to significantly increase antibody titers against both HA and NA glycoproteins of bovine A/H5N1. Recent infection with human A/H1N1 but not A/H3N2 viruses induced significant increases in bovine A/H5N1 neutralizing antibody, as well as increases in NA-binding and NA-inhibiting antibodies to bovine A/H5N1 NA. While the degree of protection afforded by these A/H5N1 cross-reactive antibodies is not known, incorporating NA or enhancing current seasonal vaccine formulations to increase NA-specific antibody responses may increase antibody breadth and protection against both seasonal and pandemic influenza viruses

Data associated with the publication: EyePose: Pose-guided saccadic eye movement video generation for deep learning-based neurologic disease phenotyping

The synthetic dataset comprises 3,000 labeled saccadic eye movement videos evenly distributed across three classes: normal, hypometria, and hypermetria. Each video simulates horizontal saccades with realistic amplitude and velocity patterns, and is annotated based on saccadic accuracy. The videos are sampled at 25 Hz with a resolution of 256×256 pixels, and span approximately 5 seconds, capturing a sequence of multiple saccadic events per clip. For each video, a corresponding waveform is provided

Data associated with the publication: Imitatecholec: A multimodal dataset for long-horizon imitation learning in robotic cholecystectomy

ImitateCholec is a publicly available, multi-modal dataset of over 18,000 ex vivo porcine cholecystectomy demonstrations. Each clipping and cutting phase is broken into 17 fine-grained tasks and captured synchronously via stereo endoscopic and wrist-mounted cameras (JPEG frames) together with da Vinci Research Kit kinematics (CSV). Both optimal executions and recovery maneuvers are included, supporting long-horizon imitation learning, workflow modeling, error recognition, and surgical tool pose estimation

Data associated with the publication: Multi-contrast laser endoscopy for in vivo gastrointestinal imaging

This repository contains data and code for replicating the data analysis presented in Multi-contrast laser endoscopy for in vivo gastrointestinal imaging. In this project, we introduce a Multi-contrast Laser Endoscopy (MLE) system with rapidly tunable spectral, coherent, and directional illumination. We demonstrate three capabilities of MLE: enhancing tissue chromophore contrast with multispectral diffuse reflectance, quantifying blood flow using laser speckle contrast imaging, and characterizing mucosal topography using photometric stereo. We validate MLE with benchtop models, then demonstrate MLE in vivo during clinical colonoscopies. The data collection is split into code and data subdirectories. Due to the larger file sizes, the dataset cannot be downloaded as a single combined .zip file, and so should be downloaded individually. Please refer to the README for instructions for reassembling the file directly organization for proper file path access by the code

Code associated with the publication: Evaluating the role of alpha cell dysregulation in the progression to type 2 diabetes using mathematical simulations

Code used in the mathematical modeling of the role of alpha-cell dysregulation on the longitudinal progression to T2D

Data associated with the publication: C3VDv2: 3D colonoscopy video dataset with enhanced realism

3D computer vision techniques could improve the diagnostic value of colonoscopy, but the lack of 3D colonoscopy datasets for training and validation hinders their development. This paper introduces C3VDv2, a high-definition Colonoscopy 3D Video Dataset with enhanced realism designed to facilitate the quantitative evaluation of 3D colon reconstruction algorithms. 192 video sequences were captured by imaging high-fidelity phantoms from two colon anatomies. Ground truth depth, surface normals, optical flow, occlusion, six-degree-of-freedom pose, coverage maps, and 3D models are provided for 169 colonoscopy videos. Eight simulated screening colonoscopy videos acquired by a gastroenterologist are provided with ground truth poses. The dataset includes 15 videos featuring colon deformations for qualitative assessment. C3VDv2 elevates realism by incorporating diverse and challenging scenarios for 3D reconstruction algorithms commonly encountered during colonoscopy procedures, such as the presence of fecal debris, mucous pools, blood, debris obscuring the colonoscope lens, en-face views, and fast camera motion. The comprehensive nature of C3VDv2 offers a robust and diverse dataset for the quantitative and qualitative evaluation of 3D reconstruction algorithms. . This work was supported in part with funding and products provided by Olympus Corporation of the Americas. Although the agreement states a Sponsored Research Agreement, Olympus is funding, but not sponsoring this research.</p

Data associated with the publication: Syngap1 and the development of murine neocortical progenitor cells

SYNGAP1 is a major regulator of synaptic plasticity through its interaction with synaptic scaffold proteins and modulation of Ras and Rap GTPase signaling pathways. SYNGAP1 mutations in humans are often associated with intellectual disability, epilepsy, and autism spectrum disorder. Syngap1 heterozygous loss-of-function in mice results in impaired LTP, premature maturation of dendritic spines, learning disabilities and seizures, reflecting the phenotypes of the human SYNGAP1 syndrome. More recently, SYNGAP1 was shown to influence cortical neurogenesis and the proliferation of progenitors in human organoids. Here, we show that the absence or haploinsufficiency of Syngap1 does not influence the properties of neocortical progenitors and their cellular output in mice. Despite careful histological analysis of progenitor numbers, division mode, and neocortical thickness, using validated staining methods and EdU labeling with positive controls, we failed to replicate the main findings from human organoids. This discrepancy highlights potential species-specific or methodological differences and raises significant questions about the broader relevance of SYNGAP1’s role in neurogenesis. The absence of cortical progenitor deficits in Syngap1 haploinsufficient mice, which exhibit cognitive deficits and seizures, indicates that these phenotypes do not arise from differences in neurogenesis but are more likely due to SYNGAP1's prominent role in the regulation of synapse function

Data and code associated with the publication: The role of attention in multi attribute decision making

This dataset includes both behavioral data and neurophysiological recordings from two male rhesus macaques performing a multi-attribute decision making tasks. Monkeys made fixations to two options with two options each presented on a screen in front of them, then indicate their decision by moving a joystick in the direction of their chosen option. Water rewards are then delivered according to the reward amount and probability attributes of the chosen option. Neural recordings are from the pre-supplementary motor area. Spike-sorted single units were obtained over a number of recording sessions for both monkeys