Monitoring Tools for the Development of High Cell Density Culture Strategies

Biopharmaceuticals market has been constantly increasing during the last years, what is transforming the manufacturing industry of biomolecules. The efforts have been put into better understanding how bioprocesses are regulated in order to firstly, build the quality of the biopharmaceuticals into the bioprocess, and secondly, to be able to develop suitable culture strategies for the implementation of intensified bioprocess while preserving the product quality attributes (product quality). Both targets strongly depend on the development of reliable monitoring tools able to measure the key bioprocess variables and parameters. Among all the available monitoring tools, spectroscopic techniques are called to be the predominant as they can offer multicomponent mixtures composition. However, such techniques have not been widely incorporated due to its complexity which hampers their adoption by the industry. Alternatively, other “soft sensors” like oxygen uptake rate (OUR), have been successfully applied for the monitoring of cell activity, being very sensible to changes in metabolic behaviour or other biochemical changes suffered by the cells. Therefore, OUR has been applied to determine the key time points (Time of Action, TOA), for example the proper time for nutrients feeding in intensified cultures, or also the Time of Harvest in virus-host cells systems. TOAs detection would allow to automate and control the bioprocesses achieving higher productivities and product quality.info:eu-repo/semantics/publishedVersio

Urban elements that facilitate esport and physical activity in regenerated públic spaces: Barcelona's waterfront

Investments in sport, events and tourism in cities and wider regions are part of nascent regeneration strategies linked to transitioning economic bases and place images. While it is important to consider physical regeneration, there is a range of subsequent benefits and opportunities brought about through regeneration that considers social impacts, communities and how investments and developments influence how people interact in transformed spaces.info:eu-repo/semantics/publishedVersio

Farmacología del sistema cardiovascular

info:eu-repo/semantics/publishedVersio

Danza creativa, expresión y salud

info:eu-repo/semantics/submittedVersio

Privacy and e-learning: a pending task

Most educational software programs use and gather personal information and metadata from students. Additionally, most of the educational software programs are no longer operated by the learning institutions but are run by third-party agencies. This means that in the decade since 2020, information about students is stored and handled outside premises and control of learning institutions. The personal information about students and their activity while they interact with learning management systems and online learning tools is increasingly in custody of cloud computing platforms, software-as-a-service providers, and learning tool vendors. There is an increasing will to use all the data and metadata from the activity of the students for research, to develop education management strategies, pedagogy approaches, and develop behavior control tools or learning tools informed by behavior analysis from learning analytics. Many times, these studies lack the ethical and moral perspective. In addition, there is an increasing number of cases in which this information has leaked or has been used in a shady way. Additionally, this information will be around for a long time, tied to the future digital profiles of the students whose data has been leaked. This paper hypothesizes that there has been an ongoing process of technological evolution that leads to a loss of control over personal information, which makes it even more difficult to protect user confidentiality and ensuring privacy, that data surveillance has entered the world of education, and that the current legal frameworks are not enough to really protect the student’s personal information. The paper analyzes how this situation came to pass, and why this is wrong. We conclude with some proposals to address it from its different root dimensions: technical, cultural, legal, and organizational.info:eu-repo/semantics/publishedVersio