Expression of the Receptor for Advanced Glycation End-Products and Its Ligands in Lung Cancer

金沢医科大学博士（医学）2013thesi

Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium

金沢医科大学博士（医学）2013thesi

Relevance of distinct monocyte subsets to clinical course of ischemic stroke patients

金沢医科大学博士（医学）2013thesi

Nutri-pharmacogenomics of warfarin anticoagulation therapy : VKORC1 genotype-dependent influence of dietary vitamin K intake

金沢医科大学博士（医学）2013thesi

MRI reveals edema in larynx (but not in brain) during anaphylactic hypotension in anesthetized rats

金沢医科大学博士（医学）2013thesi

Myocardial sympathetic innervation, function, and oxidative metabolism in non-infarcted myocardium in patients with prior myocardial infarction

金沢医科大学博士（医学）2013thesi

Salvage Surgery after Pembrolizumab Treatment for Squamous Cell Carcinoma of the Thyroid Gland: A Case Report and Review of the Literature

Background/Aim: Squamous cell carcinoma of the thyroid is a rare disease with a poor prognosis, and a standard treatment has not yet been established. Case Report: This report details the response of an 80-year-old woman diagnosed with squamous cell carcinoma of the thyroid to pembrolizumab treatment. She was referred to our hospital with the chief complaints of hoarseness and dyspnoea. Further examination revealed a tumour in the left lobe of the thyroid gland infiltrating the left side of the thyroid cartilage, along with oedema in the left lumbar region and left recurrent nerve palsy. Owing to the risk of asphyxia, the patient was urgently admitted to the hospital, and tracheotomy and tumour biopsy were performed. Subsequently, primary squamous cell carcinoma of the thyroid gland (cT4aN0M0) was diagnosed. The patient did not wish to undergo surgical treatment; therefore, radiotherapy was administered, but it proved ineffective and was subsequently discontinued. Biopsy tissue analysis indicated a combined positive score >20; consequently, pembrolizumab was introduced, which exhibited a notable antitumour effect which led to a significant reduction in tumour size. Positron emission tomography-computed tomography performed during the course of treatment revealed FDG enhancement of the tumour, indicating reaggravation. Following consultation with the patient, total thyroidectomy and laryngectomy were performed. Postoperative histopathology unexpectedly revealed no evidence of squamous cell carcinoma in the tumour tissue, and only papillary carcinoma of the thyroid gland. This suggests that pembrolizumab may have resulted in the complete resolution of squamous cell carcinoma of the thyroid gland. Conclusions: Pembrolizumab may be an effective treatment modality for squamous cell carcinoma of the thyroid.journal articl

Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation

Oxidative stress is a major risk factor for calcium oxalate nephrolithiasis. Reports suggest that oxidative stress response is induced in animals and humans with kidney stones. Keap1, Nrf2, and HO-1 are known as oxidative stress mediators. However, the association between oxidative stress response and stone formation is unclear. In this study, we analyzed oxidative stress response from the acute to the crystal formation phase when crystal formation was applied to renal crystal mice model and bioimaging mice and investigated the effect on crystal formation. In renal tissues, after glyoxylate administration, HO-1 increased for up to 6 h and returned to baseline at 24 h. This was observed following each daily dose until five days after the crystallization phase; however, the range of increase was attenuated. The possibility that Nrf2 activity influenced the number of crystals was considered in the experiment. Crystal formation increased in Nrf2-deficient mice and could be reduced by Nrf2 activators. In conclusion, the oxidative stress response via the Keap1-Nrf2 pathway may contribute to crystal formation. Particularly, this pathway may be a prospective target for drug development to prevent and cure nephrolithiasis.journal articl