3D structural insights into the effect of N-glycosylation in human chitotriosidase variant G102S

東北医科薬科大学博士（薬科学）令和6年度doctoral thesi

The Experience and Creativity of a Pharmacist in Home Care: A Sociological Examination of the Life History of Medical Professionals

departmental bulletin pape

Fucosyltransferase 4 upregulates P-gp expression for chemoresistance via NF-κB signaling pathway

東北医科薬科大学博士（薬科学）令和6年度doctoral thesi

Exogenous L-fucose attenuates depression induced by chronic unpredictable stress: implicating core fucosylation has an antidepressant potential

東北医科薬科大学博士（薬科学）令和6年度doctoral thesi

O-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway

東北医科薬科大学博士（薬科学）令和6年度doctoral thesi

Each N-glycan on human IgA and J-chain uniquely affects oligomericity and stability

東北医科薬科大学博士（薬科学）令和5年度doctoral thesi

Chemical constituents of five Saxifraga species and their virucidal activities

The chemical constituents of Saxifraga stolonifera, S. fortunei, S. nipponica, S. cortusifolia, and S. rebunshirensis were investigated for structure and virucidal activity. In addition to the Saxifraga species-derived tannins, 30 compounds (1−30) were isolated from the five species. 5-Hydroxy-4-methoxy-3-O-(6-O-caffeoyl)-β-D-glucopyranosyl benzoic acid (1) and kaempferol 3-O-β-d-xylopyranosyl-(1 → 2)-β-D-xylopyranoside (2) were identified as undescribed compounds. Although 1 was isolated as the (E)-isomer of its caffeoyl moiety, under light it became over time a mixture of the (Z)-isomer (1a) and (E)-isomer (1). Kaempferol 3-O-β-d-xylopyranosyl-(1 → 2)-β-D-glucopyranoside (3) was an analog of 2 and a known compound, whose NMR assignment was reconsidered and described. 6-Isopropyl-5,5-dimethyldihydropyrimidine-2,4(1H,3H)-dione (30) was expected to be a racemic mixture based on its optical rotation and X-ray crystallography data. The virucidal activities of the isolated compounds (1–30) against influenza A virus, severe acute respiratory syndrome coronavirus 2, feline calicivirus, and murine norovirus were evaluated to identify the presence of compounds other than the Saxifraga species-derived tannins, which exhibited virucidal activities. Although the isolated compound activities were relatively weak compared to those of Saxifraga species-derived tannins, the potential virucidal activity of the compounds with galloyl groups was confirmed.journal articl

Cover, Contents, Colophon

departmental bulletin pape

Abstracts of Published Papers and Titles of Papers Presented at Scientific Meeting 【Faculty of Medicine】

departmental bulletin pape

Attitude towards linkage between maternal and child health information and school health information: responses among participants in a birth cohort study

In recent years, with advances in information technology, the use of personal health records from birth through the rest of life has come to be advocated. Therefore, it is essential to understand the current status of people's awareness of this issue. The purpose of this study is to investigate the attitudes towards linking maternal and child health information with school health checkup information, by asking participants of birth cohort participants. Participants in the BOSHI study, a birth cohort study, were asked by postal questionnaire regarding the linkage of maternal and child health information and school health check-up information and received responses from 366 of the 1203 participants（valid response rate: 30.4%）. A high proportion（more than 75%）felt that maternal and child health information and school health check-up information needed to be linked, while about half of the respondents also felt that confirmation of consent was necessary every time the information was made available. The proportion of those who thought that confirmation of consent was necessary when information was used by external researchers such as universities and companies was more than 65%, which was particularly high. In 2021 compared to 2020, the proportion of those who answered that the information from before conception should be linked increased significantly, and the percentages of those who answered that confirmation of consent was required every time the government or local authorities used their information also increased. While awareness of the importance of health information linkage is high and the range of linkage is expanding, more careful explanations are required for its utilization.departmental bulletin pape