Phytochemical and biological investigations of medicinal plants (Woodsia ilvensis, Artemisia sieversiana, and Rheum undulatum) for promoting the health of livestock in Mongolia

東北医科薬科大学博士（薬科学）令和6年度doctoral thesi

Antimicrobial stewardship program における広域抗菌薬の選択に関する研究

東北医科薬科大学博士（薬学）令和6年度doctoral thesi

Isolation of Antiplasmodial Oxazoles and Isoflavonoids from the Roots of Oxytropis trichophysa and Total Synthesis of Oxazole-type Alkaloids

A chemical examination of a root extract of Oxytropis trichophysa led to the isolation and identification of 23 compounds, including oxazole-type alkaloids and isoflavonoid derivatives. Notably, three oxazole-type alkaloids (1, 2, and 3) and two isoflavonoid derivatives (7 and 10) were obtained from a natural source for the first time. In addition, O. trichophysa derived 2,5-diphenyloxazoles and their derivatives were synthesized. Despite their potential activity, the antiplasmodial activities of naturally occurring 2,5-diphenyloxazoles and certain isoflavonoids remain unexplored. Therefore, the antiplasmodial activities of both the naturally occurring and synthesized compounds were evaluated against Plasmodium falciparum strain 3D7. Among the tested compounds, three naturally occurring oxazole-type alkaloids (1, 5, and 6), one synthesized alkaloid (34), and two isoflavonoid derivatives (13 and 15) demonstrated significant inhibitory effects, with half-maximal inhibitory concentration (IC50) values ranging from 3.1 to 6.2 μM and selective indices between 0.9 and 18.8. Compound 1 showed the most potent inhibitory activity, with an IC50 of 3.1 μM, while its cytotoxic concentration 50% value against human foreskin fibroblasts was found to be 8.5 μM. The oxazole-type alkaloids and isoflavonoids isolated from this plant provide valuable insights into its chemical composition and may help elucidate the antiplasmodial properties of O. trichophysa.journal articl

The acetylglucosaminyltransferase GnT-Ⅲ regulates erythroid differentiation through ERK/MAPK signaling

東北医科薬科大学博士（薬科学）令和6年度doctoral thesi

A Study on Medical English Suffixes -Especially on Nousns That Indicate Types of Medicines-

departmental bulletin pape

気管支喘息におけるCGRP-ILC2軸の活性化と肺神経内分泌細胞の過形成機構に関する研究

東北医科薬科大学博士（薬学）令和6年度doctoral thesi

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departmental bulletin pape

Colophon

departmental bulletin pape

Reports on the 72nd Meeting for Higher Education in Tohoku-Hokkaido area

departmental bulletin pape

Isolation of Sesquiterpenoids and Trypanocidal Constituents from Artemisia adamsii

The Mongolian Artemisia adamsii (A. adamsii) plant is of particular interest from both medicinal and ecological perspectives. In this study, three previously undescribed sesquiterpenoids (1–3) were isolated, along with 25 known compounds, from naturally dried and browned aerial parts of A. adamsii, which were collected in the autumn from the pasturelands of Bayan Soum, Tuv Province, Mongolia. The chemical structures of the isolated undescribed compounds, including their relative and absolute configurations, were elucidated by high-resolution mass spectrometry, nuclear magnetic resonance spectroscopy, and single crystal X-ray crystallography. The trypanocidal activities of the isolated compounds against six species, namely Trypanosoma brucei brucei, T. b. gambiense, T. b. rhodesiense, T. equiperdum, Trypanosoma congolense, and Trypanosoma evansi were evaluated. Consequently, a coumarin (fraxetin) and a flavonoid (jaceosidin) were identified as exhibiting relatively potent activities. Quantitative analysis by high-performance liquid chromatography confirmed relatively high contents of these compounds in A. adamsii, indicating that they represent the main functional components of this plant. These results further demonstrate the potential medicinal and ecological significance of A. adamsii.journal articl