Central Asian Journal of Medical and Natural Science
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Оценка Частоты Встречаемости Аритмий Сердца И Показателей Реполяризации Желудочков У Больных С Гипертоническим Кризом
В данном исследование было изучено частота встречаемости аритмий у больных с гипертоническим кризом которые, обратились за медицинской помощью в Самаркандский региональный филиала Республиканского специализированного научного-практического медицинского центра кардиологии (СРФ РСНПМЦК) за период 2020-2022 гг. Объектами исследования являлись 123 больных с гипертонической болезнью (ГБ) осложненным гипертоническим кризом. По результатам было выявлено, что у больных с ГБ III стадии, осложненной гипертоническим кризом, достоверно чаще, чем в ГБ II стадии, регистрируются нарушение сердечного ритма всех градаций, причем с нарастанием степени AГ увеличивается класса по Lown
Analysis of Viral Load in Patients with HIV and Patients with HIV/TB
Among people living with the human immunodeficiency virus (HIV), tuberculosis (TB) is the most common concomitant disease and the leading cause of mortality. HIV-positive test results for confirmed TB patients increased from 58 percent in 2016 to 60 percent in 2017
Определение Влияния Рутана На Биотрансформацию И Глюкуронирование Лекарственных Средств На Модели Острого Токсического Гепатита
Эксперимент натижасида СсL4 (тетрахлорметан) ли ўткир токсик гепатитда танинли ўсимлик Rhus coriaria L. дан ажратилган Рутан полифенолининг дорилар биотрансформацияси ва глюкуронизациясига таъсири туфайли барбитурик уйқуни қисқартиришида намоён бўлади. Бу натижалар ўткир токсик гепатитда легалон ва рутаннинг жигарнинг сафро ҳосил қилиш функциясига фойдали таъсирининг асосини ташкил этувчи гепатоцитларнинг моноксигеназа фермент тизимларининг функционал фаоллигини тиклайди
Оценка Эффективности Антиспаечного Покрытия На Модели Раны Легкого В Эксперименте
Эксперименты формированию раны легкого с последующей оценкой эффективности антиспаечного покрытия из производных целлюлозы выполнены на базе многопрофильной клиники СамГМУ, отделении хирургии в 2022 году. В качестве экспериментальных животных использованы белые беспородные крысы в количестве 32 особей. Всего выполнено 2 серии экспериментов контрольная и опытная группы
Principles of Revascularization in Treatment of Large and Giant Cerebral Aneurysms
Over the past decades, the interest of neurosurgeons in extra-intracranial anastomoses has increased significantly, especially in the context of their use in the treatment of large and giant aneurysms. The development of microsurgical techniques and neuroanesthetic techniques, adequate selection of patients for surgery, achievements in neuroradiology and monitoring of cerebral blood flow are prerequisites for the improvement of revascularization surgery. The development of competitive endovascular methods of treatment, in turn, pushes neurosurgeons to improve the microneurosurgical technique of revascularization and develop new approaches to the treatment of intracranial aneurysms. In this review, we present the principles of cerebrovascular anastomosis surgery in the treatment of large and giant aneurysms used in our clinic
Особенности Лечения Кариеса Зубов У Детей Раннего И Дошкольного Возраста
В настоящее время санация полости рта является одним из важнейших методов профилактики кариеса зубов у детей. Под влиянием прогресса в стоматологической практике совершенствуются не только пломбировочные материалы, но и методы лечения кариеса зубов [87, 136, 185]. По литературным данным, существуют новые методы препарирования твердых тканей зубов для лечения кариеса временных зубов [5, 19, 56, 87, 111, 126, 184, 197,219, 239]
Impact of Thromboembolism Prevention of Anticoagulant Therapy on the Course and Outcome of Covid-19
This article focuses on the impact of thromboembolism prevention on the course and outcome of anticoagulation therapy in COVID-19, and provides effective ways to manage and treat patients with coronavirus
Ultrasound Diagnostics and Diapeutics of Focal Liquid Lesions of the Liver
The development of modern medical technologies has significantly increased the efficiency of diagnosis and treatment of various diseases. Early verification of pathological changes in organs and tissues became possible even before the appearance of the first symptoms of the disease or its complications. In this regard, the frequency of early detection of focal liquid lesions of the liver, such as cysts and abscesses, has increased, which has led to a relative increase in the number of patients with these diseases
Evaluation of miR-204 Serum Level in Obese Patients with Type 2 Diabetes
Background The failure of the pancreatic islets to maintain normal blood glucose concentrations is not observed in clinical manifestations until irreversible damage has occurred. There is no effective biomarker yet to predict type 2 diabetes. MicroRNAs (miRNAs) are single non-coding RNA molecules. And miRNAs play a vital role in inhibiting the translation of post-transcriptional mRNAs. Studies in recent years have revealed that these microparticles play an essential role in the pathogenesis of type 2 diabetes. In addition, the presence of miRNAs in serum and plasma also provides a potential target for detecting disease markers. This study aims to investigate miR-204 in obese patients with type 2 diabetes.
Methods: Here we had collected 180 blood samples from 60 normal individuals, 60 patients with T2DM with a BMI of less than 30 and 60 patients with T2DM with a BMI of more than 30. The age of the subjects was 48-72 years . That's 85 males and 95 females. We used real-time Stem-loop PCR to detect miR-204 in the plasma of obese patients with type 2 diabetes.
Results: The results showed that plasma miR-204 levels were increased significantly in patients with T2DM in compared to normal individuals (P>0.001). Then we were also showed that serum miR-204 in Obese- T2DM groups were significantly higher than non-Obese- T2DM group. (2-sided Student’s t test P < 0.001). the results showed that there was no significant relationship between age and sex with miR-204 (P=0. 591 and 0.490 for age and sex, respectively). Our results showed that there was a statistical significant difference between BMI of all individuals with miR-204 expression. We showed that 56.1% of none obese individuals were low expression of miR-204 suggesting that increasing BMI leads to increasing level of miR-204 (P=0.001).
Conclusion: The Measuring circulating miR-204 is provide a relatively simple and straight forward approach, making it attractive for potential wider clinical application. However, identifying miR-204 could provide the necessary sensitivity and specificity to be detected in T2D
Аспекты Дисфункции Тиреоидных Гормонов Щитовидной Железы
В нашей работе отмечены аспекты дисфункции гормонов щитовидной железы основываясь на литературные источник