Innovative approach for self-management and social welfare of children with Cystic Fibrosis in Europe: development, validation and implementation of an mHealth tool (MyCyFAPP).

Introduction For the optimal management of children with cystic fibrosis, there are currently no efficient tools for the precise adjustment of pancreatic enzyme replacement therapy, either for advice on appropriate dietary intake or for achieving an optimal nutrition status. Therefore, we aim to develop a mobile application that ensures a successful nutritional therapy in children with cystic fibrosis. Methods and analysis A multidisciplinary team of 12 partners coordinate their efforts in 9 work packages that cover the entire so-called 'from laboratory to market' approach by means of an original and innovative co-design process. A cohort of 200 patients with cystic fibrosis aged 1-17 years are enrolled. We will develop an innovative, clinically tested mobile health application for patients and health professionals involved in cystic fibrosis management. The mobile application integrates the research knowledge and innovative tools for maximising self-management with the aim of leading to a better nutritional status, quality of life and disease prognosis. Bringing together different and complementary areas of knowledge is fundamental for tackling complex challenges in disease treatment, such as optimal nutrition and pancreatic enzyme replacement therapy in cystic fibrosis. Patients are expected to benefit the most from the outcomes of this innovative project. Ethics and dissemination The project is approved by the Ethics Committee of the coordinating organisation, Hospital Universitari La Fe (Ref: 2014/0484). Scientific findings will be disseminated via journals and conferences addressed to clinicians, food scientists, information and communications technology experts and patients. The specific dissemination working group within the project will address the wide audience communication through the website (http://www.mycyfapp.eu), the social networks and the newsletter

Fantasmes de la tradició. Sobre l'assaig contemporani i les seues arrels en l'edat moderna

El nostre objectiu és establir una sèrie de línies de continuïtat entre l'assaig europeu de l'edat moderna i el desenvolupament de l'assaig català contemporani, amb l'aparició del Glosari d'Eugeni d'Ors (1906) com a fita principal. Així, analitzarem els models formals i els referents literaris disponibles en el tombant dels segles xix i xx, amb una atenció especial a la tradició assagística de base francesa i alemanya, il·lustrada i romàntica. Tot seguit, ens centrarem en les condicions materials en què es van escriure, editar i llegir aquests textos, sobretot pel que fa al desenvolupament de la premsa i l'edició contemporània, factors que facilitaren l'emergència de la figura de l'intel·lectual. En darrer lloc, examinarem com l'assaig contemporani dialoga amb la tradició pròpia, tant en termes lingüístics com literaris

English for Tourism - Unit 6 Review Activities

El material docente titulado "English for Tourism - Unit 6 Review Activities" está diseñado como un recurso complementario para reforzar el aprendizaje del inglés en el ámbito del turismo especializado. Basado en la Unidad 6 del libro "English for International Tourism" de Pearson (niveles B1-B2), este material proporciona actividades enfocadas en el vocabulario, las expresiones y la gramática esenciales para describir sectores específicos del turismo. La primera sección del material introduce vocabulario clave sobre los distintos sectores del turismo especializado, como el turismo de bienestar, el turismo culinario, el turismo de vida silvestre y el turismo genealógico, entre otros. Se presentan términos en inglés con sus correspondientes traducciones al español, permitiendo a los estudiantes ampliar su conocimiento sobre los diversos tipos de turismo y su terminología específica. Además, se incluyen términos descriptivos que ayudan a caracterizar mejor cada tipo de turismo. Palabras como "sacred site", "extreme weather" y "canopy walkway" permiten que los estudiantes comprendan mejor las condiciones y características de cada destino. También se incorporan expresiones útiles que pueden emplearse en contextos profesionales para describir experiencias turísticas, recomendar actividades y destacar aspectos culturales y ambientales. En la sección de gramática, el material se centra en el uso de verbos seguidos por infinitivo o por la forma -ing, un aspecto clave para mejorar la precisión lingüística en la comunicación oral y escrita. Se explican las reglas gramaticales con ejemplos claros y contextualizados, permitiendo a los estudiantes diferenciar cuándo utilizar cada estructura de manera adecuada. El material incluye una serie de ejercicios prácticos para consolidar el aprendizaje. Entre ellos, se encuentran actividades de emparejamiento de sectores turísticos con sus descripciones, ejercicios de completar oraciones con la forma correcta de los verbos y una práctica de escritura en la que los estudiantes deben redactar oraciones sobre experiencias en turismo especializado utilizando correctamente los verbos con infinitivos o -ing. Este recurso está estructurado de manera clara y progresiva, facilitando la retención del contenido y promoviendo su aplicación en contextos reales del sector turístico. Su enfoque práctico y contextualizado lo convierte en una herramienta valiosa para mejorar la competencia lingüística de los estudiantes y prepararlos para una comunicación efectiva en entornos internacionales y profesionales del turismo

Comunidad Valenciana

49 x 60 c

Methodology for burned areas delimitation and fire severity assessment using Sentinel-2 data. A case study of forest fires occurred in Spain between 2018 and 2023

The objective of this article was to develop a methodology for the burned areas delimitation and fire severity assessment in forest fires occurred in Spain between 2018 and 2022. As input data, this study was based on the use of Sentinel-2 spectral indices, which are characterized by having spectral bands in the near-infrared (NIR) and short-wave infrared (SWIR) spectral regions, allowing a high distinction between burned and unburned areas, and between different fire severity degrees too. All possible combinations between Sentinel-2 bands applied to a spectral normalized difference index (SP) were analyzed, along with the most commonly used burn spectral indices in remote sensing as the Burned Area Index (BAI), the Burned Area Index for Sentinel-2 (BAIS2), the Mid-Infrared Burn Index (MIRBI), the Normalized Burn Ratio (NBR), the Relativized Burn Ratio (RBR) and the relative differential Normalized Burn Ratio (RdNBR). In addition, in order to delete confusions between burned area and the presence of other land cover areas, the Sentinel-2 Global Land Cover (S2GLC 2017) and the temporal differences between pre-fire and post-fire dates were obtained for each spectral index (dSP). The results were compared by: in the case of burned areas, the Emergency Mapping Service (EMS) and the Galicia forest service; in the case of fire severity, using field plots classified as in Ruiz-Gallardo et al. (2004) study (null, low, moderate and high severity). The final statistic results obtained showed that the dNBR2 spectral index (using B11 and B12 Sentinel-2 spectral bands) provided the highest results of burned area delimitation (7% of commission error and 3% omission error, respectively) whereas, the combination of the BAIS2, the NBR and the modified Normalized Burn Ratio (NBR2, using B7 and B12 Sentinel-2 spectral bands), used in areas with low, mix and full vegetation respectively, provided the highest results in fire severity assessment (kappa statistic, F1-score and Balanced Accuracy equal to 0.87, 0.86 and 0.92, respectively). The methodology developed in this work allows obtaining accurate maps of burned area and fire severity in Spain, contributing to the reinforcement of national forest fires statistics

High-gradient testing of an S-band, normal-conducting low phase velocity accelerating structure

A novel high-gradient accelerating structure with low phase velocity, v/c=0.38, has been designed, manufactured and high-power tested. The structure was designed and built using the methodology and technology developed for CLIC 100  MV/m high-gradient accelerating structures, which have speed of light phase velocity, but adapts them to a structure for nonrelativistic particles. The parameters of the structure were optimized for the compact proton therapy linac project, and specifically to 76 MeV energy protons, but the type of structure opens more generally the possibility of compact low phase velocity linacs. The structure operates in S-band, is backward traveling wave (BTW) with a phase advance of 150 degrees and has an active length of 19 cm. The main objective for designing and testing this structure was to demonstrate that low velocity particles, in particular protons, can be accelerated with high gradients. In addition, the performance of this structure compared to other type of structures provides insights into the factors that limit high gradient operation. The structure was conditioned successfully to high gradient using the same protocol as for CLIC X-band structures. However, after the high power test, data analysis realized that the structure had been installed backwards, that is, the input power had been fed into what is nominally the output end of the structure. This resulted in higher peak fields at the power feed end and a steeply decreasing field profile along the structure, rather than the intended near constant field and gradient profile. A local accelerating gradient of 81  MV/m near the input end was achieved at a pulse length of 1.2  μs and with a breakdown rate (BDR) of 7.2×10-7  1/pulse/m. The reverse configuration was accidental but the operating with this field condition gave very important insights into high-gradient behaviour and a comprehensive analysis has been carried out. A particular attention was paid to the characterization of the distribution of BD positions along the structure and within a cell

Effects of Accentuated Eccentric and Maximal Strength High-Resistance Training Programs with or Without a Curcumin-Based Formulation Supplement on Body Composition, Blood Pressure, and Metabolic Parameters in Older Adults.

Abstract Background/objectives: This study compared the effects of high-resistance training (RT) programs, with or without curcumin supplementation, on variables commonly associated with metabolic syndrome (MetS), including body composition, blood pressure, and metabolic parameters. Methods: Eighty-one older adults at risk of MetS (BMI > 25 kg/m2, fat mass > 32%, and systolic blood pressure > 130 mmHg in half of the participants) were randomly assigned to six groups, which were comprised as follows: four experimental groups involving either accentuated eccentric or maximal strength RT with curcumin or placebo and two control groups receiving either curcumin or placebo. Experimental groups completed a 16-week full-body RT with elastic bands, while controls did not exercise. Results: The results showed that (I) all experimental protocols significantly reduced fat mass (p ≤ 0.001), with the maximal strength RT group supplemented with curcumin (Max-Cur) showing the greatest reduction, at 14.3%; (II) muscle gains were significant and comparable across experimental groups (p ≤ 0.008); (III) both systolic and diastolic blood pressure decreased similarly across experimental groups (p ≤ 0.001); (IV) metabolic parameters significantly improved across experimental groups (p ≤ 0.037), except for creatinine, which showed an undesirable peak only in the Max-Cur group; (V) curcumin supplementation enhanced the effects of both RT programs; and (VI) between 54% and 100% of participants achieved clinically meaningful improvements in seven out of ten MetS-related variables across experimental groups. Conclusions: Our findings indicate that high-RT programs combined with curcumin supplementation positively impacted all MetS-related variables. The Max-Cur RT group stood out as the most beneficial, with the greatest fat mass reductions, highlighting this approach as a promising strategy to reduce the risk of MetS in older adults. Keywords: creatinine; elastic bands; fat and muscle mass; glycemia; lipid profile; rating of perceived effort; strength trainin

Draft genome of Leisingera aquaemixtae CECT 8399T, a member of the Roseobacter clade isolated from a junction of fresh and ocean water in Jeju island, South Korea

We report the draft genome sequence and annotation of Leisingera aquaemixtae CECT 8399(T) (DDBJ/EMBL/GenBank accession number CYSR00000000) which comprises 4,614,060 bp, 4313 protein coding genes, 54 tRNA coding genes and 7 rRNA coding genes. General findings of the annotated genome, such as pigment indigoidine operon, phenylacetate oxidation genes or predictable number of replicons, are commented in comparison to other Leisingera species. Average Nucleotide Identity between available genomes of type strains of species of Leisingera and Phaeobacter genera has been calculated to evaluate its current classification

Psychosocial and environmental motivational key factors behind the parenthood desire in infertile couples at the time of COVID-19

Purpose: To evaluate the main psychosocial motivational factors behind the increased adoption of IVF during the COVID-19 pandemic. Methods: This prospective, multicenter, observational case-control study assessed the factors motivating infertile couples to pursue their first IVF treatment during the pandemic across various IVF clinics in Spain, Portugal, Italy, the USA, and Panama. A pre-pandemic control group and a post-pandemic participant group were surveyed. The study was conducted between November 2021 and January 2023. The increase in IVF cycles was analyzed, and an ad hoc survey was developed to explore the motivational factors driving IVF engagement. Results: Most clinics reported a significant increase in IVF demand (5.5-8.7%) for all indicators, including the number of started ovarian stimulations, oocyte pickups, and embryo transfers, following the declaration of the pandemic. The extra time spent and the reduced workload were the most important motivations prompting women to pursue their first fertility treatment during the pandemic (time to spend in the couple's relationship OR, 1.53; 95% CI, 1.06-2.20; p < 0.05; decreased workload OR, 2.63; 95% CI, 1.11-6.24; p < 0.05). Conclusion: This study highlights that infertility remains a significant stressor for individuals, and the desire to resolve it is not hindered by catastrophic events like COVID-19. Open communication between partners about reproductive intentions, combined with reduced work-related stress, is a key factor influencing the initiation of fertility treatment. It is crucial to encourage couples to take timely action in facing infertility

Fixed points of continuous nonlinear mappings in Banach spaces

The purpose in this article is to discuss under what conditions a nonexpansive or a condensing mapping has a fixed point when its domain is a closed, convex subset of a Hilbert space and its range is not necessarily contained within its domain. When the mapping is completely continuous and its domain is a closed, convex subset of a uniformly convex Banach space a similar result is also investigated. We also deal with the existence of fixed points of condensing mappings whose domain is the closure of an open subset of an arbitrary Banach space