Nazarbayev University

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    7338 research outputs found

    Le paysage de la décolonisation de la métropole Hong Kong-Macao

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    Les facteurs apolitiques qui dirigent la mondialisation de l'économie sont en train de brutalement détruire l'architecture vernaculaire chinoise ainsi que le riche symbolisme lié à l'aménagement traditionnel du paysage. Le but de cet article est plus précisément de proposer une description des effets sur l'environnement du retour à la Chine des dernières colonies européennes en Asie orientale

    The c-ros tvrosine kinase receptor I controls regionalization and differehiation of epithelial cells in the epididymis

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    The c-ros gene was originally identified in mutant form as an oncogene. The proto-oncogene encodes a tyrosine kinase receptor that is expressed in a small number of epithelial cell types, including those of the epididymis. Targeted mutations of c-ros in the mouse reveal an essential role of the gene in male fertility. Male c-ros -1- animals do not reproduce, whereas the fertility of female animals is not affected. We demonstrate that c-ros is not required in a cell autonomous manner for male germ cell development or function. The gene, therefore, does not affect sperm generation or function in a direct manner. The primary defect in the mutant animals was located in the epididymis, showing that c-ros controls appropriate development of the epithelia, particularly regionalization and terminal differentiation. The epididymal defect does not interfere with production or storage of sperm but, rather, with sperm maturation and the ability of sperm to fertilize in vivo. Interestingly, sperm isolated from c-ros - / - animals can fertilize in vitro. Our results highlight the essential role of the epididymis in male fertility and demonstrate a highly specific function of the c-ros receptor tyrosine kinase during development of distinct epithelial cell

    Molecular-dynamics simulation of thin-film growth by energetic cluster impact

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    Langevin-molecular-dynamics simulations of thin-film growth by energetic cluster impact were carried out. The impact of a Mo 1043 cluster on a Mo(001) surface was studied for impact energies of 0.1, 1, and 10 eV/atom using the Finnis-Sinclair many-body potential. The characteristics of the collision range from a soft touchdown at 0.1 eV/atom, over a flattening collision at 1 eV/atom, to a meteoric impact at 10 eV/atom. The highest energy impact creates a pressure of about 100 GPa in the impact zone and sends a strong shock wave into the material. The cluster temperature reaches a maximum of 596 K for 0.1 eV/atom, 1799 K for 1 eV/atom, and 6607 K for 10 eV/atom during the first ps after the touchdown. For energies of 1 and 10 eV/atom the cluster recrystallizes after 20 ps. The consecutive collision of 50 Mo 1043 clusters with a Mo(001) surface at T=300 K was simulated for the three impact energies. The formation of a porous film is calculated for clusters impinging with low kinetic energy, while for the clusters with the highest energy a dense mirrorlike film is obtained, in good agreement with experiment

    Equality and equity: An emerging government policy in northern ireland

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    A series of equality and equity measures has been introduced by the British Government to tackle the seemingly intractable problems of Northern Ireland. These measures represent a range of initiatives in the areas of social need, fair employment, education reform and community relations. The implementation of the community relations programme is considered in some detail as a case study in improving equality and equity in Northern Ireland. Qualitative data from community relations officers, charged with implementing the policy, are examined in the light of problems encountered with the programme. The influences on delivering community relations, as one component of this comprehensive thrust to attain equality and equity, are also considered using an explanatory model. The article concludes that changes in attitudes and behaviour between the two communities are occurring, albeit slowly, promoted by the measures described. © 1994, Taylor & Francis Group, LLC. All rights reserved

    Scatter Factor/Hepatocyte Growth Factor and Its Receptor, the c-met Tyrosine Kinase, Can Mediate a Signal Exchange between Mesenchyme and Epithelia during Mouse Development

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    Scatter factor/hepatocyte growth factor (SF/HGF) has potent motogenic, mitogenic, and morphogenetic activities on epithelial cells in vitro. The cell surface receptor for this factor was recently identified: it is the product of the c - m e t protooncogene, a receptor-type tyrosine kinase. We report here the novel and distinct expression patterns of SF/HGF and its receptor during mouse development, which was determined by a combination of in situ hybridization and RNase protection experiments. Predominantly, we detect transcripts of c - m e t in epithelial cells of various developing organs, whereas the ligand is expressed in distinct mesenchymal cells in close vicinity. In addition, transient SF/HGF and c - m e t expression is found at certain sites of muscle formation; transient expression of the c - m e t gene is also detected in developing motoneurons. SF/HGF and the c-met receptor might thus play multiple developmental roles, most notably, mediate a signal given by mesenchyme and received by epithelial. Mesenchymal signals are known to govern differentiation and morphogenesis of many epithelia, but the molecular nature of the signals has remained poorly understood. Therefore, the known biological activities of SF/HGF in vitro and the embryonal expression pattern reported here indicate that this mesenchymal factor can transmit morphogenetic signals in epithelial development and suggest a molecular mechanism for mesenchymal epithelial interactions

    The clusters growth and evaporation rate constante calculation by using of molecular dynamics method for condensation behind the shock front

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    Molecular dynamics model of calculation of the growth and evaporation rate constants of dusters is proposed. Calculations for small clusters are carried out. On the basis of the chemical mechanism the characteristic time of condensation is achieved, which is in available agreement with experiment on condensation of iron vapors behind the shock front

    Existence, Uniqueness, and Numerical Analysis of Solutions of a Quasilinear ParabolicProblem

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    A quasilinear parabolic problem is studied. By using the method of lines, the existence and uniqueness of a solution to the initial boundary value problem with sufficiently smooth initial conditions are shown. Also given are L2 error estimates for the error between the extended fully discrete finite element solutions and the exact solution

    REAL TIME PREDICTIVE CONTROL OF UR5 ROBOTIC ARM THROUGH HUMAN UPPER LIMB MOTION TRACKING

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    This thesis reports the authors’ results on developing a real-time predictive control system for an Universal Robot UR5 robotic arm through human motion capture with a visualization environment built in the Blender Game Engine. The UR5 is a 6 degree of freedom serial manipulator commonly used in academia and light industry. It is a very safe robot by design that comes at a cost of a rather limited API with very little support of real-time operation. The motion tracking is performed by a wireless low-cost inertial motion capture setup produced in-house. The motion tracker is an extension of author’s previous work on replacing a forearm IMU in conventional inertial motion tracking suits with a potentiometer in order remove anatomical constraints from corresponding data fusion algorithms. The external controller incorporates an iTaSC SDLS IK solver and a Python wrapped C explicit model predictive controller generated using the Multi Parametric Toolbox. The visualisation provides the user with the feedback on the robot’s progress towards the target. It is planned to extend the visualisation to virtual reality in future. Tests have shown that the robot follows the operator’s wrist position and orientation with an average of 0.05sec. time lag in the case when the operator moves under the robot’s velocity and acceleration limits. When the operator moves too fast for the robot to keep up in real-time, the robot is able to catch up with the operator with little or no overshooting. Thesis results are described in a late-breaking report and demo accepted by the 12th annual IEEE/ACM international conference Human-Robot Interaction (HRI2017)

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