The Impact of DDR1 on Bone Material Properties

Decreased bone density and deterioration of bone tissue are hallmarks of age-related bone loss. This arises from an imbalance of bone cell regulation, including increased osteoclast (bone-resorbing cell) and decreased osteoblast (bone-forming cell) activity, which collectively affect the collagenous extracellular matrix. Certain cell-surface receptors found in these bone cells can change the content of bone by regulating cell growth and affecting the collagen and mineral content. One such receptor is Discoidin Domain Receptor 1 (DDR1), which binds to collagen type I in bone and affects both matrix mineralization and collagen fibrillogenesis, the effects of which are still being explored. In previous studies we elucidated how lack of DDR1 impaired osteoclast count and increased stiffness in 6-month (mo) murine femurs. This discrepancy, a decrease in bone building cells and an increase in stiffness, may be explained by the underlying matrix environment. In this study we investigated how DDR1 affects the bone collagen and mineral content in 6-mo mice. Femurs were taken from 6-mo female DDR1 knock-out (KO) and wild type (WT) mice. Mid-shaft cortical sections were subjected to Picrosirius Red staining and transmission electron microscopy. To analyze mineral quantity, tissue mineral density, bone mineral density, and thermogravimetric analyses were performed. Our investigations revealed that the DDR1 KO mice had a significant increased mineral percent composition throughout the whole bone matched with a trend towards increase in mineral density in the cortical region. The fibril diameter was enhanced in KO mice while the D-periodicity exhibited no change across genotypes. The collagen fiber packing and size were reduced in the KO model. These results suggest that DDR1 regulates the collagen quality and mineral quantity in the bone, which may in turn regulate bone loss.MARC T34 ProgramA one-year embargo was granted for this item.Academic Major: Mechanical Engineerin

A Grain Size Analysis of Southern Cascadia Marine Sediment

The intention behind this research was to better understand the grain size of fourteen previously untested cores from the Southern Cascadia Subduction Zone. A better understanding of grain size from this area could be useful in an improved understanding of hazards associated with seismic activity. Another goal of this research was to lay groundwork for more research to be done in the future. Samples were collected from the United States Geological Survey Coastal and Marine Science Center core repository in Santa Cruz, California. One to two gram samples were collected every two centimeters from cores JPC 1, 4, 5, 6, 31, 32, 34, 35, 36, 37, 38, 39, 40, and 41 and then analyzed for grain size at The Ohio State University Marine Geology and Geohazards Laboratory. Grain size was determined with a Horiba Partica LA – 960V2 laser diffraction grain size analyzer. The data was plotted in standard ternary plots, percent-finer graphs, and downcore grain size graphs for each core. The overwhelming majority of cores were silt-dominated. There were also several instances of fining upward in the downcore grain size graphs for many cores. This suggests possible records of sediment gravity deposits in those areas.Cooperative Grant - (AWD115192) (PI Dr. Derek Sawyer)A one-year embargo was granted for this item.Academic Major: Earth Science

Characterizing Ruminal T Cells in Lactating Dairy Cows.

γδ T cells regulate immune responses via Interleukin-10 secretion and reduces cytotoxic and helper T cell proliferation, in vitro. γδ T cells are prominent in ruminant peripheral blood but their presence in rumen tissue remains unclear. Our study aimed to determine the relative proportions of T-cell types within rumen tissue, hypothesizing that the largest proportion would be γδ T-cells. Using an observational study, 3 ruminally cannulated Holstein dairy cows were monitored for 21 days. Dry matter intake and milk yield were measured daily. Milk samples, body condition scores, and bodyweight were assessed on d 2 and 9. Rumen pH was measured every 4 h for 24 h on d 2 and 11. Partial rumen evacuations on d 8 and 15 facilitated rumen tissue samplings for flow cytometric analysis. Blood samples for peripheral immune cell analysis were collected on d 8 and 15 immediately after rumen evacuations. Spectral flow cytometry assessed T cell proportions in blood and rumen tissue using a panel including CD45+ (leukocytes), CD3+ (T lymphocytes), CD4+ (Helper T cells), and TCRN-24+ (γδ T cell). Flow cytometry data were analyzed in JMP with a linear mixed model blood vs. rumen tissue. The cows remained clinically healthy, with dry matter intake at 26.0 ± 3.44 kg/d, and milk at 50.6 ± 12.99 kg/d (Mean ± SD). Rumen pH was within a normal range (6.06 ± 0.55). CD3+ cells constituted 95.6% ± 8.3% (Mean ± SEM) of all ruminal CD45+ cells compared to 63.6% ± 8.3% in blood. On aCD3+ basis, TCRN24+ cells were the most prominent subset of T lymphocytes in rumen tissue and were enriched compared to blood (87.9% ± 2.4% v. 6.5 ± 2.4%). The CD4+ were not enriched in the rumen compared to blood (0.7% ± 1.1% vs. 14.7 ± 1.1%). We observed a TCRN24+CD4+ population in the rumen which was largely absent in blood (6.6% ± 1.3% vs. 0.4 ± 1.3%). Understanding the role of T lymphocytes in rumen immunity may guide strategies to strengthen health and digestion while reducing inflammation in ruminants.No embargoAcademic Major: Animal Science

Council on Academic Affairs: Minutes (January 22, 2025)

Minutes from the Council on Academic Affairs' meeting on January 22, 2025

Establishing a Unique Social Identity in the Entertainment Industry: A Case Study of a Japanese Female Artist

This study reports a case study of how Ano, a female Japanese artist, constructs a unique identity through two linguistic choices: her distinctive voice quality and the use of the masculine first-person pronoun boku instead of traditional feminine pronouns like watashi or atashi. By analyzing her TV program episodes, interviews, live broadcasts, and song lyrics, the study shows that Ano adopts a cute and childlike tone and uses boku to create a unique persona that represents who she is. The motivations behind these choices include her struggle with public speaking anxiety and a desire to avoid feminine connotations associated with traditional pronouns. The study highlights the role of language choices in shaping identity within the entertainment industry

Comic Fascism: Ideology, Catholicism, and Americanism in Italian Children's Periodicals

Item embargoed for three year

Empathetic Pedagogy: Fostering Inclusivity in Library Instruction for Neurodiverse Learners

As neurodivergent librarians, we are well aware that the traditional classroom structure doesn’t always meet our neurodivergent students where they are. Through the discovery of our own neurodiversity and newly recognized cognitive needs, we refined our own teaching practices to be more equitable and to extend more intentional empathy toward our students. With this in mind, we have continued our previous best practices using universal design for learning (UDL), but shifted our practice to create an even more inclusive and brave space to begin or continue the process of learning with librarians. In this chapter, we share techniques that can be adapted from one-shot sessions through to full credit-bearing courses, for traditional and non-traditional students alike. With a focus on Empathetic Pedagogy, we begin by outlining practices that emphasize mindful teaching, deliberate interventions, and a positive shift in perspective in perceiving learners, particularly those who are neurodiverse. This includes UDL techniques, such as scaffolding to enhance the acquisition of knowledge, providing resources in multiple formats, and varying the types of assignment submissions. We also share strategies for fostering a supportive teaching environment during high-stress periods of the semester. This includes effective approaches to offering assistance and creating space for students to express emotions, even those considered 'undesirable,' as they can contribute to persistence and learning. We also incorporate the use of open pedagogy to promote learner agency and ensure equitable access to resources. Open pedagogy prioritizes creating brave spaces for learning, prioritizing care and compassion. Open pedagogy offers three major benefits for students with neurodiversity. Fostering student autonomy throughout instruction empowers learners to engage with course content according to their preferences and strengths, promoting greater success and achievement. This approach proves beneficial for students exhibiting a Persistent Drive for Autonomy or Pathological Demand Avoidance (PDA) profile, allowing them the flexibility to choose their preferred methods of engagement. Scaffolding conceptual frameworks and technological tools throughout the learning experience equips students with the essential support necessary for their success. Additionally, it offers the opportunity to provide supplementary context they may need, ensuring a comprehensive understanding of the subject matter. Empowering students as content creators not only enhances instructor-student relationships by spotlighting student expertise and autonomy but also serves as a platform to cultivate empathy. This is achieved through intentional check-ins at the commencement and conclusion of each class, building a continuous thread of connection throughout the entire learning journey. To round out these strategies, we recommend adopting the addition of learning technology into our lessons that intentionally aids students battling executive dysfunction to fully embrace an empathetic pedagogical approach to teaching for neurodivergent students. Our hope is for our readers to become more reflective in their current teaching practices, finding ways to incorporate these strategies into their own. With a gentle and slow shift in the ways we approach our teaching, we aim for the field as a whole to become more friendly to the neurodiversity of both our student populations, as well as our colleagues.Publisher allows immediate open acces

Local Nursing Legends Class of 2025

2025 Annual Friends of Nursing History Lecture, "Local Nursing Legends: Class of 2025", May 15, 2025, Prior Hall, Room 550, The Ohio State University Medical Center Campus, Columbus, Ohio.The Local Nursing Legends program honors our fourth class of local nursing legends. Pioneers in their field, these five nurses were nominated by members of the central Ohio nursing community and approved by the Medical Heritage Center Friends of Nursing History Steering Committee for making a significant contribution to the nursing profession and the health care of people in central Ohio