〈Research Notes〉 A Study Method of Old Japanese Grammar and Vocabulary for Foreign Students (4) : The case of Case particles and Conjunctive particles

publisher専攻: 日本文

古書瑣談

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〈Translations〉Werner Beulke, Strafprozessrecht, 11. Auflage (2010 C. F. Muller, Heidelberg) ( 5 )

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〈近畿大学医学会特別講演抄録〉環境応答信号伝達経路とがん

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〈Translations〉Robert Esser, Zur Bestellung des Verteidigers im Ermittlungsverfahren--Pladoyer fur eine Reform des §141 Abs.3 StPO im Lichte der EMRK und der EU-Richtlinie zum Recht auf Rechtsbeistand, in: Festschrift fur Hans-Heiner Kuhne, 2013, S. 539—563

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〈Originals〉 COX-2 expression and the prevalence of regulatory T cells in tumor and non-tumor sites of hepatocellular carcinoma

publisher[Abstract] Aim : The expression of cyclooxygenase-2 (COX-2) plays a role in the differentiation and guidance of regulatory T cells (FOXP3^+ Tregs), and this mechanism has also been studied extensively in hepatocellular carcinoma (HCC). In this study, we investigated the expression of COX-2 and prevalence of FOXP3^+ Tregs in tumor and non-tumor sites to elucidate their association with the clinicopathological features of HCC and disease outcome. Method : This study involved 44 patients with HCC who had undergone hepatectomy without any preoperative treatment. Paraffin-embeddednodules (n=44) were sectioned for immunostaining with COX-2 and FOXP3 monoclonal antibodies, and the degree of COX-2 expression and prevalence of FOXP3^+ Tregs were measured. Results : COX-2 expression in the non-tumor sites showed a positive correlation with the number of FOXP3^+ Tregs (p < 0.001). In addition, in the non-tumor sites, the high FOXP3^+ Tregs prevalence group was significantly associated with TNM stages (p=0.003) and AFP (p=0.027). The expression of COX-2 in the nontumor sites was also significantly associated with disease-free survival (p=0.005). Conclusion : The present findings suggest the association of COX-2 expression in the nontumor sites with disease-free survival and thus the recurrence of HCC. In addition, COX-2 expression and the prevalence of FOXP3^+ Tregs have been positively correlated in the non-tumor sites, indicating that their interaction influences the outcome of HCC. To prevent the recurrence of HCC, it may be necessary to inhibit the expression of COX-2

化学研磨浴添加剤としての--ジガルボン酸の効果

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<Original Papers>Study on the Evaluation of the Bus Services for the Elderly People in a Local Town

publisher[Synopsis] In Kumano-cho the Hiroshima Electric Railway bus which is an only public transportation was management aggravation, the some routes were abolished in 2006. Kumano-cho is as high ratio as more than 30% of aging rates, and the town locates in hillside. The existence of many hills and slopes has been the obstacle of resident's daily-life. Therefore, decrease in bus services made residents inconvenient. It has been an important subject to secure elderly people's transportation devices in this town. The workshops were held in 2011. There residents argued about the view and necessity for a life transport planning for aging people. At the result a plan in consideration of residents request was drawn up. Based on this plan, a free bus service was carried out from July, 2012 for half an year. The bus system was called the Odekakego, and a taxi with a capacity of nine-passengers was used. By the user number and their requests and opinions the bus services were revised again, and it carried out newly from April, 2013. Here the actual conditions and an analysed results were shown, and a sustainable bus system in future was considered

年頭所感

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Reduced Glomerular Filtration Rate Is Associated with Atheroma Progression in Early-stage Diabetes Patients with Coronary Artery Disease--Sub-analysis from DIANA study

publisher[Abstract] Background: With strong links among chronic kidney disease (CKD), diabetes, and cardiovascular mortality, the need for effective risk stratification and management of diabetic patients has emerged. The aim of the present study was to characterize CKD and assess the impact ofrenal function and effects of glycemic control on atheroma progression in diabetic patients with coronary artery disease (CAD). Methods : Early-stage diabetic patients with CAD in the DIANA study (n＝301) was stratified according to the presence of reduced glomerular filtration rate (GFR, ＜60 ml/min). Clinical characteristics and metabolic data were compared between the two groups. Atheroma progression was assessed one year after treatment by quantitative coronary angiography and the impact of glycemic improvement was analyzed. Results : Patients with reduced GFR (32% of the cohort)were older (p＜0.01)and showed high preva-lence of impaired glucose tolerance (IGT) (p＝0.03). They also showed significantly smaller vessel size at baseline. There were trends toward less improvement in the glycemic status and less increase of HDL cholesterol in patients with reduced GFR (p＝0.09 and 0.05, respectively). In patients with non-reduced GFR, antiatherosclerotic effects were observed in patients achieving improvement of the glycemic status (p＝0.02). In contrast, atheroma progression was similar between reduced-GFR patients with and without optimal glycemic control (p＝0.24). Conclusions : While glycemic control was associated with less atheroma progression in early-stage diabetic patients with non-reduced GFR, this positive impact was diminished in those with reduced GFR. The present findings may suggest a more resistant substrate of coronary atherosclerosis in diabetic patients with CKD and the need for strict risk factor management to prevent atheroma progression