Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model

Despite remarkable advances, radiation therapy (RT) remains inefficient for some bulky tumors, radioresistant tumors, and certain pediatric tumors. Minibeam radiation therapy (MBRT) has emerged as a promising approach, reducing normal tissue toxicity while enhancing immune responses. Preclinical studies using X-rays and proton MBRT have demonstrated enhanced therapeutic index for aggressive tumor models. Combining MBRT's advantages of spatial dose fractionation with the physical and biological benefits of carbon ions could be a step further toward unleashing the full potential of MBRT. This study aims to perform the first in vivo study of local and systemic responses of a subcutaneous mouse osteosarcoma (metastatic) model to carbon MBRT (C-MBRT) versus conventional carbon ion therapy (CT). Irradiations were conducted at the GSI Helmholtz Centre in Germany using 180 MeV/u 12C ions beam. All irradiated animals received an average dose (20 Gy) and displayed a significant and similar tumor growth delay in addition to a decreased metastasis score compared to the non-irradiated group. In the C-MBRT group, 70% of the tumor volume received the valley dose, which is a very low dose of 1.5 Gy. The remaining 30% of the tumor received the peak dose of 105 Gy, resulting in an average dose of 20 Gy. These results suggest that C-MBRT triggered distinct mechanisms from CT and encourage further investigations to confirm the potential of C-MBRT for efficient treatment of radioresistant tumors

Diagnostics of Spin-Polarized Ions at Storage Rings

Polarized heavy ions in storage rings are seen as a valuable tool for a wide range of research, from the study of spin effects in relativistic atomic collisions to the tests of the Standard Model. For forthcoming experiments, several important challenges need to be addressed to work efficiently with such ions. Apart from the production and preservation of ion polarization in storage rings, its measurement is an extremely important issue. In this contribution, we employ the radiative recombination (RR) of polarized electrons into the ground state of initially hydrogen-like, finally helium-like, ions as a probe process for beam diagnostics. Our theoretical study clearly demonstrates that the RR cross section, integrated over photon emission angles, is highly sensitive to both the degree and the direction of ion polarization. Since the (integrated) cross-section measurements are well established, the proposed method offers promising prospects for ion spin tomography at storage rings.Keywords: spin-polarized ions; radiative recombination; integrated recombination cross sectio