Sipario (Teatro antico) / Curtain (ancient Theatre)

Uso e funzione del sipario nel teatro antic

La motivazione alla lettura dei giovani adulti: esiti di una ricerca esplorativa.

Il contributo approfondisce il tema della motivazione alla lettura dei giovani adulti. Le ricerche nazionali di settore evidenziano come la disaffezione nelle pratiche di lettura sia particolarmente evidente alla fine del secondo ciclo di istruzione. In Italia, i lettori sono pochi e concentrati in fasce d'età specifiche. Lo scopo della ricerca è esplorare cosa intendono i giovani adulti per “motivazione alla lettura” al fine di identificare, in prospettiva, strategie e pratiche che possano favorire abitudini di lettura permanenti. Lo studio ha coinvolto studenti della scuola secondaria di secondo grado e studenti universitari iscritti al Dipartimento di Scienze della Formazione dell’Università Roma Tre, provenienti da vari corsi di laurea. La ricerca è di natura esplorativa e si è basata su un campione di convenienza non probabilistico. Hanno partecipato in totale 1.371 studenti. I dati sono stati rilevati utilizzando un questionario semi-strutturato che indaga sulle abitudini di lettura e sul significato attribuito al concetto di motivazione alla lettura. L'analisi dei dati è stata condotta attraverso un'analisi tematica bottom-up, che ha permesso lo sviluppo di un modello categoriale multidimensionale sulla motivazione alla lettura. I risultati dello studio mirano a contribuire al dibattito scientifico sulle strategie didattiche e sulle migliori pratiche in grado di supportare lo sviluppo di lettori consapevoli, capaci di mantenere nel tempo il loro interesse per la lettura

Why a Serf is Not a Slave: Humans and Land in the Medieval Scholastic Imagination.

This article re-examines the medieval legal category of servus glebae (“serf of the soil”) in the context of the scholastic jurists’ engagement with Roman law and their influence on social change. Starting from James Q. Whitman’s call for “grand theories” in legal history, it explores how medieval legal imagination—conceived as a distinct, rational world of categories—shaped both the conceptualization and the practical realities of property and personal status. Moving beyond Marc Bloch’s dismissal of the term’s applicability to medieval serfdom, the study demonstrates that scholastic jurists deliberately distinguished between the Roman colonate and feudal servitude, framing the latter either as a personal status or as a form of real servitude over persons. Through the works of Azo and other glossators, it shows how dialectical reasoning and precise legal qualifications influenced municipal statutes, limited landlords’ powers, and supported emancipation measures such as Bologna’s Liber Paradisus (1257). The analysis situates these doctrinal developments within broader processes of the thirteenth century, including the monetization and eventual abolition of feudal rights, the emergence of dominium utile, and the consolidation of “perfect property.” Rejecting the separation of legal scholarship from social reality, the article argues that medieval jurisprudence actively structured social relations, with lasting effects on European legal thought

Isolation and characterization of extracellular vesicles from EGFR mutated lung cancer cells

The epidermal growth factor receptor (EGFR) signaling pathway is essential for cellular processes such as proliferation, survival, and migration. Dysregulation of EGFR signaling is frequently observed in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. This study aims to isolate and characterize extracellular vesicles (EVs) released by mutant EGFR lung cancer cell line PC9 and compare them with wild-type EGFR lung cancer cell line A549, while also evaluating the effect of gefitinib treatment on EV secretion and cargo composition. The two lung cancer cell lines were cultured with 2% EV-free serum, and EVs were subsequently isolated by differential ultra centrifugation. EVs were characterized by nanoparticle tracking analysis (NTA) and transmission electron microscopy (TEM) for quantification size and shape determination. Western blot analysis confirmed the enrichment and purity of isolated EVs. Results showed that EGFR mutation significantly increased EV release and altered their size, compared to EVs released by wild-type EGFR cells. In addition to classical EV markers such as CD81, Flotillin- 1, and TSG101, Western blot analysis also detected phosphorylated EGFR (p-EGFR) selectively packaged into EVs from PC9 cells. Gefitinib treatment significantly reduced EV secretion in PC9 cells and led to a marked decrease in p-EGFR incorporation into EVs, indicating that EV biogenesis and compostion are modulated by active EGFR signaling. In conclusion, this study highlights the significant influence of EGFR activation on EV secretion and cargo composition while demonstrating that EGFR inhibition via gefitinib alters EV-mediated signaling in lung cancer cells. These findings provide insights into tumor behavior, EV-mediated oncogenic communication, and the potential use of EVs as biomarkers and therapeutic targets in NSCLC

Patrimonio Italiano in Portogallo. Un viaggio nei secoli XV-XX

Il volume descrive attarverso 18 saggi diversi aspetti della presenza di artisti, letterati e architetti italiani in Portogallo dalla fine del medioevo all'età contemporane

Versatile MDM-OFDM system with selectable single-mode half-subcarrier or two-mode full-subcarrier multiplexing

We propose a novel all-optical hybrid MDM-OFDM system that enables variable transmission capacity by seamlessly switching between two-mode full subcarriers and single-mode sparse subcarriers multiplexing through the use of power loading. The operation depends on the mode crosstalk present between the arrayed waveguide grating and the two-mode fiber. Through rigorous analysis, our results indicate that for the two-mode full subcarrier multiplexing, a power loading of 0.78 dB for the TE10 mode guarantees uniform performance across all subcarriers. Furthermore, by effectively suppressing the TE10 mode using a power loading of 12 dB, our system achieves similar performances and functionality to single-mode sparse subcarrier multiplexing, wherein only the TE00 mode is utilized. Our system offers variable transmission rates for data center connections, using all-optical signal processing, without varying the modulation scheme and the symbol rate