32,369 research outputs found
Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3.
The T cell antigen receptor consists of the Ti alpha/beta heterodimer which recognizes antigen, and the associated CD3 chains, thought to be involved in signal transduction. To understand the nature of the interaction between Ti and CD3, chimeric molecules which included the COOH-terminal segments of Ti alpha or beta linked to the extracellular segment of CD8, were transfected into a mutant T cell deficient in Ti beta chain expression and cell surface CD3. Both chimeric chains were required to express the chimeric Ti and to restore CD3 surface expression. CD8/Ti and CD3 cointernalized and coimmunoprecipitated. Stimulation of the chimeric receptor induced transmembrane signaling events and cell activation. These results demonstrate that the Ti alpha and beta COOH termini containing the transmembrane domains are sufficient for structural and functional coupling of Ti to CD3
Optical Properties of Quantum-Dot-Doped Liquid Scintillators
Semiconductor nanoparticles (quantum dots) were studied in the context of
liquid scintillator development for upcoming neutrino experiments. The unique
optical and chemical properties of quantum dots are particularly promising for
the use in neutrinoless double beta decay experiments. Liquid scintillators for
large scale neutrino detectors have to meet specific requirements which are
reviewed, highlighting the peculiarities of quantum-dot-doping. In this paper,
we report results on laboratory-scale measurements of the attenuation length
and the fluorescence properties of three commercial quantum dot samples. The
results include absorbance and emission stability measurements, improvement in
transparency due to filtering of the quantum dot samples, precipitation tests
to isolate the quantum dots from solution and energy transfer studies with
quantum dots and the fluorophore PPO.Comment: version 2, minor text update
Baffling of fluid sloshing in cylindrical tanks Final report
Annular baffle for damping liquid oscillations in partially filled cylindrical tan
Identification of Coulomb blockade and macroscopic quantum tunneling by noise
The effects of Macroscopic Quantum Tunneling (MQT) and Coulomb Blockade (CB)
in Josephson junctions are of considerable significance both for the
manifestations of quantum mechanics on the macroscopic scale and potential
technological applications. These two complementary effects are shown to be
clearly distinguishable from the associated noise spectra. The current noise is
determined exactly and a rather sharp crossover between flux noise in the MQT
and charge noise in the CB regions is found as the applied voltage is changed.
Related results hold for the voltage noise in current-biased junctions.Comment: 6 pages, 3 figures, epl.cls include
System characterization of positive real conditions
Necessary and sufficient conditions for positive realness in terms of state space matrices are presented under the assumption of complete controllability and complete observability of square systems with independent inputs. As an alternative to the positive real lemma and to the s-domain inequalities, these conditions provide a recursive algorithm for testing positive realness which result in a set of simple algebraic conditions. By relating the positive real property to the associated variational problem, a unified derivation of necessary and sufficient conditions for optimality of both singular and nonsingular problems is derived
Sequence of the mouse Q4 class I gene and characterization of the gene product
The Q4 class I gene has been shown to participate
in gene conversion events within the mouse major
histocompatibility complex. Its complete genomic nucleotide
sequence has been determined. The 5' half of Q4
resembles H-2 genes more strongly than other Q genes.
Its 3' end, in contrast, is Q-like and contains a translational
stop signal in exon 5 which predicts a polypeptide with
an incomplete membrane spanning segment. The presence
of two inverted B1 repeats suggests that part of the Q4
gene may be mobile within the genome. Gene transfer experiments
have shown that the Q4 gene encodes a
ß2-microglobulin associated polypeptide of Mr 41 000. A
similar protein was found in activated mouse spleen cells.
The Q4 polypeptide was found to be secreted both by
spleen cells and by transfected fibroblasts and was not detectable
on the cell surface. Antibody binding and twodimensional
gel electrophoresis indicate that the Q4
molecule is identical to a mouse class I polypeptide, Qb-1,
which has been previously described
Magnetic buoyancy instabilities in the presence of magnetic flux pumping at the base of the solar convection zone
We perform idealized numerical simulations of magnetic buoyancy instabilities in three dimensions, solving the equations of compressible magnetohydrodynamics in a model of the solar tachocline. In particular, we study the effects of including a highly simplified model of magnetic flux pumping in an upper layer (‘the convection zone’) on magnetic buoyancy instabilities in a lower layer (‘the upper parts of the radiative interior – including the tachocline’), to study these competing flux transport mechanisms at the base of the convection zone. The results of the inclusion of this effect in numerical simulations of the buoyancy instability of both a preconceived magnetic slab and a shear-generated magnetic layer are presented. In the former, we find that if we are in the regime that the downward pumping velocity is comparable with the Alfvén speed of the magnetic layer, magnetic flux pumping is able to hold back the bulk of the magnetic field, with only small pockets of strong field able to rise into the upper layer.
In simulations in which the magnetic layer is generated by shear, we find that the shear velocity is not necessarily required to exceed that of the pumping (therefore the kinetic energy of the shear is not required to exceed that of the overlying convection) for strong localized pockets of magnetic field to be produced which can rise into the upper layer. This is because magnetic flux pumping acts to store the field below the interface, allowing it to be amplified both by the shear and by vortical fluid motions, until pockets of field can achieve sufficient strength to rise into the upper layer. In addition, we find that the interface between the two layers is a natural location for the production of strong vertical gradients in the magnetic field. If these gradients are sufficiently strong to allow the development of magnetic buoyancy instabilities, strong shear is not necessarily required to drive them (cf. previous work by Vasil & Brummell). We find that the addition of magnetic flux pumping appears to be able to assist shear-driven magnetic buoyancy in producing strong flux concentrations that can rise up into the convection zone from the radiative interior
Magnetic Miniband Structure and Quantum Oscillations in Lateral Semiconductor Superlattices
We present fully quantum-mechanical magnetotransport calculations for
short-period lateral superlattices with one-dimensional electrostatic
modulation. A non-perturbative treatment of both magnetic field and modulation
potential proves to be necessary to reproduce novel quantum oscillations in the
magnetoresistance found in recent experiments in the resistance component
parallel to the modulation potential. In addition, we predict oscillations of
opposite phase in the component perpendicular to the modulation not yet
observed experimentally. We show that the new oscillations originate from the
magnetic miniband structure in the regime of overlapping minibands.Comment: 6 pages with 4 figure
Scaling and data collapse for the mean exit time of asset prices
We study theoretical and empirical aspects of the mean exit time of financial
time series. The theoretical modeling is done within the framework of
continuous time random walk. We empirically verify that the mean exit time
follows a quadratic scaling law and it has associated a pre-factor which is
specific to the analyzed stock. We perform a series of statistical tests to
determine which kind of correlation are responsible for this specificity. The
main contribution is associated with the autocorrelation property of stock
returns. We introduce and solve analytically both a two-state and a three-state
Markov chain models. The analytical results obtained with the two-state Markov
chain model allows us to obtain a data collapse of the 20 measured MET profiles
in a single master curve.Comment: REVTeX 4, 11 pages, 8 figures, 1 table, submitted for publicatio
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