Addressing the speed-accuracy simulation trade-off for adaptive spiking neurons

The adaptive leaky integrate-and-fire (ALIF) model is fundamental within computational neuroscience and has been instrumental in studying our brains $\textit{in silico}$. Due to the sequential nature of simulating these neural models, a commonly faced issue is the speed-accuracy trade-off: either accurately simulate a neuron using a small discretisation time-step (DT), which is slow, or more quickly simulate a neuron using a larger DT and incur a loss in simulation accuracy. Here we provide a solution to this dilemma, by algorithmically reinterpreting the ALIF model, reducing the sequential simulation complexity and permitting a more efficient parallelisation on GPUs. We computationally validate our implementation to obtain over a $50\times$ training speedup using small DTs on synthetic benchmarks. We also obtained a comparable performance to the standard ALIF implementation on different supervised classification tasks - yet in a fraction of the training time. Lastly, we showcase how our model makes it possible to quickly and accurately fit real electrophysiological recordings of cortical neurons, where very fine sub-millisecond DTs are crucial for capturing exact spike timing.Comment: 15 pages, 5 figure

Integrating Glenohumeral Range of Motion with Dynamic Postural Control for Early Detection of Elbow Injury Risk in Collegiate Baseball Pitchers: A Preliminary Prospective Case Series

Introduction: Medial elbow ulnar collateral ligament (UCL) injuries are common in baseball with increased surgical incidence in pitchers. There is no consensus on which modifiable injury risk metrics or performance screening tools to use to identify at risk collegiate baseball pitchers. Current literature on UCL injury risk has focused on local passive glenohumeral rotational motion with limited forays into more global movement patterns. The aim of this study was to assess possible relationships involving UCL injuries and modifiable local and global motor control performance risk factors. Material and Methods: An observational single cohort case series involving 15 collegiate baseball pitchers aimed to elucidate disparitites in glenohumeral active and passive range of motion alongside an assessment of general movement competency and dynamic motor control performance to identify injury risk for the UCL. Preseaon baseline metrics, including the Functional Movement Screen, Upper and Lower Quarter Y Balance Test, and glenohumaral internal and external rotation active, passive, and total arc range of motion were examined. Results: The two pitchers with UCL injury demonstrated less ability to actively move into their available passive rotational range with decreased lower extremity dynamic postural control, but no difference with general movement competency. The pitcher requiring UCL surgical intervention demonstrated even greater excessive passive range compared to the other injured pitcher and a decreased ability to control base of support during the dynamic single-leg balance performance test. Discussion: Participants with UCL injuries exibited noticable deficiencies in baseline active and passive mobility, suggestive of a potential motor control deficit and a compromised ability to fully access available range of motion. Furthermore, diminished performance on the Lower Quarter Y Balance Test identified potential motor control limitations involving a decreased ability to dynamically maintain a base of support. Conclusions: This is the first study designed to identify motor control issues in the both the local shoulder region and global body movement to identify modifiable risk factors for UCL injuries in baseball pitchers. This study may begin to address the gap in the literature by combining modifiable local shoulder range of motion and global balance metrics to identify pitchers at risk for UCL injuries. It underscores the significance of comparing active and passive range of motion in tandem with dynamic postural control assessments to better evaluate the risk of injuries in baseball pitchers. This case series lays the groundwork for future randomized clinical trials to evaluate the utiliity of combining this information

Seeking Asylum Adolescents Explore the Crossroads of Human Rights Education and Cosmopolitan Critical Literacy

Urban middle school students utilize human rights education and cosmopolitan critical literacy to explore local and global issues around immigrants and refugees through the production of a BYOT short film

Neuroimaging of Sudden Unexpected Death in Epilepsy (SUDEP): Insights From Structural and Resting-State Functional MRI Studies

The elusive nature of sudden unexpected death in epilepsy (SUDEP) has led to investigations of mechanisms and identification of biomarkers of this fatal scenario that constitutes the leading cause of premature death in epilepsy. In this short review, we compile evidence from structural and functional neuroimaging that demonstrates alterations to brain structures and networks involved in central autonomic and respiratory control in SUDEP and those at elevated risk. These findings suggest that compromised central control of vital regulatory processes may contribute to SUDEP. Both structural changes and dysfunctional interactions indicate potential mechanisms underlying the fatal event; contributions to individual risk prediction will require further study. The nature and sites of functional disruptions suggest potential non-invasive interventions to overcome failing processes

Australian bat lyssavirus infection in two horses

In May 2013, the first cases of Australian bat lyssavirus infections in domestic animals were identified in Australia. Two horses (filly-H1 and gelding-H2) were infected with the Yellow-bellied sheathtail bat (YBST) variant of Australian bat lyssavirus (ABLV). The horses presented with neurological signs, pyrexia and progressing ataxia. Intra-cytoplasmic inclusion bodies (Negri bodies) were detected in some Purkinje neurons in haematoxylin and eosin (H&E) stained sections from the brain of one of the two infected horses (H2) by histological examination. A morphological diagnosis of sub-acute moderate non-suppurative, predominantly angiocentric, meningo-encephalomyelitis of viral aetiology was made. The presumptive diagnosis of ABLV infection was confirmed by the positive testing of the affected brain tissue from (H2) in a range of laboratory tests including fluorescent antibody test (FAT) and real-time PCR targeting the nucleocapsid (N) gene. Retrospective testing of the oral swab from (H1) in the real-time PCR also returned a positive result. The FAT and immunohistochemistry (IHC) revealed an abundance of ABLV antigen throughout the examined brain sections. ABLV was isolated from the brain (H2) and oral swab/saliva (H1) in the neuroblastoma cell line (MNA). Alignment of the genome sequence revealed a 97.7% identity with the YBST ABLV strain

Livestock Protection Tools for California Ranchers

Conflicts between livestock and predators are perhaps inevitable, especially on extensively managed rangelands This publication helps producers evaluate livestock lethal and non-lethal protection tools that may fit their site-specific needs

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism

PMCID: PMC3640080This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited