Vulvovaginal candidiasis (VVC) is the second normal of vaginal mucosal infection after bacterial that influencing
right around 70%-75% of women once in a lifetime. Azoles antibiotics are used in treatment for VVC but limited
because cause drug resistance in patients. Therefore, today need for new antifungal agents for Candida albicans
infection that safe and without side effect. This article reviews Indonesian medicinal plants related to the antifungal
activity and mechanisms of action against C. albicans. The searches for this review were conducted via the databases
PubMed, Google Scholar, online Science Direct, Science and Technology Index. The document relevant analyzed and
included in the study. Almost 34 medicinal plants used for anti-Candida in Indonesia were reported. About 5.88% and
94.12% of Indonesian medicinal plants were significant and weak as an anti-Candida activity, respectively. The plants
with the greatest anti-Candida activity were Curcuma xanthorrhiza and Syzygium aromaticum. The anti-Candida
action involved disruption of hyphae production, membrane permeabilization, cell wall, biofilm formation, envelope,
and filament formation. These results contribute to the drug discovering of the anti-Candida from Indonesian
medicinal plants
