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SRC signaling in cancer and tumor microenvironment
Authors
A Birbrair
A Birbrair
+133 more
A Carlucci
A Goldman
A Kumar
A Parkin
A Patel
A Tomar
A Tsubouchi
AA Farooqi
AI Daud
AJ Cozzo
AL Berrier
AP Belsches-Jablonski
AP Czernilofsky
AR Horwitz
B Moy
B Sen
C Gridelli
C Oneyama
C Vera
CE Turner
CH Heldin
CL Abram
CW Lee
D Mukhopadhyay
D Stehelin
DA Hsia
DC Sgroi
DL Wheeler
E Avizienyte
E Ingley
EC Gaffarogullari
F Palacios
FN Soki
G Manning
GE Gallick
GS Martin
GW McLean
I Amata
J Araujo
J Lilien
JA Cooper
JA Gelderloos
JA Moroco
JD Bjorge
JE Cortes
JH Lee
JL Boerner
JL Tsang
JM Summy
JS Ahn
JS Biscardi
JT Parsons
JT Parsons
K Lawler
K Shiga
KF Harris
KW Harder
L Kuo
LA Cary
LE Arias-Romero
LN Puls
M Guarino
M Guarino
M Guarino
M Okada
MC Frame
MC Frame
MC Frame
MD Resh
MD Resh
ME Irwin
MJ Demers
MP Playford
MP Vincenti
MR Burnham
MS Collett
MT Brown
MT Kloth
MV Barone
MW Salter
MW Sim
N Prenzel
NM Wang
O Hantschel
P Friedl
P Patwardhan
PA Bromann
PA Rous
R Amanchy
R Ishizawar
R Kanteti
R Roskoski Jr
R Roskoski Jr
R Zaidel-Bar
RB Irby
RB Irby
RK Hansen
S Huveneers
S Huveneers
S Roche
S Van Slambrouck
S Zhang
S Zhu
SC Yip
SE Byeon
SJ Parsons
SM Frisch
SM Thomas
ST Liu
SY Chen
T Bowman
T Holbro
T Hunter
T Kamei
T Masaki
T Matsuoka
T Takeya
TC Beadnell
TJ Boggon
TJ Yeatman
TS Nakagawa
V Petrova
VJ Fincham
W Longmate
W Wu
X Ling
X Wu
XM Zheng
XN Meng
Y Dai
Y Lu
Z Songyang
Z Wang
Publication date
1 January 2021
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
PubMed: 33123993Pioneering experiments performed by Harold Varmus and Mike Bishop in 1976 led to one of the most influential discoveries in cancer research and identified the first cancer-causing oncogene called Src. Later experimental and clinical evidence suggested that Src kinase plays a significant role in promoting tumor growth and progression and its activity is associated with poor patient survival. Thus, several Src inhibitors were developed and approved by FDA for treatment of cancer patients. Tumor microenvironment (TME) is a highly complex and dynamic milieu where significant cross-talk occurs between cancer cells and TME components, which consist of tumor-associated macrophages, fibroblasts, and other immune and vascular cells. Growth factors and chemokines activate multiple signaling cascades in TME and induce multiple kinases and pathways, including Src, leading to tumor growth, invasion/metastasis, angiogenesis, drug resistance, and progression. Here, we will systemically evaluate recent findings regarding regulation of Src and significance of targeting Src in cancer therapy. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
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Ege University Institutional Repository
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oai:gcris.ege.edu.tr:11454/614...
Last time updated on 23/11/2023
Ege University Institutional Repository
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oai:gcris.ege.edu.tr:11454/700...
Last time updated on 23/11/2023
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Last time updated on 11/08/2021