CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Synthesis of axially disubstituted silicon phthalocyanines and investigation of their in vitro cytotoxic/phototoxic anticancer activities
Authors
Z. Biyiklioglu
K. Ocakoglu
+4 more
D. Ozel
E.T. Saka
A. Tunçel
F. Yurt
Publication date
1 January 2020
Publisher
'World Scientific Pub Co Pte Lt'
Doi
Cite
Abstract
In this study, two SiPcs have been selected and the photodynamic therapy potentials were evaluated of the Pcs. Synthesis of Axially 2-decyn-1-oxy disubstituted Es-SiPc-2 was newly synthesized by the reaction of SiPcCl2 with 2-decyn-1-ol in the presence of NaH in toluene. Furthermore, their nuclear imaging potentials were evaluated in human colon adenocarcinoma (HT-29) and human lung fibroblast cell (WI-38) cell lines. The uptake results have indicated that Es-SiPc labeled with 131I radionuclide (131I-Es-SiPc) was approximately 2-fold higher in the HT-29 cell line than the WI-38 cell line. In other words, the target/non-target tissue ratio is defined as two in the HT-29/WI-38 cell lines. Besides, the uptake values of 131I-Es-SiPc were found to be higher than 131I-Es-SiPc-2. 131I-Es-SiPc and 131I-Es-SiPc-2 are promising for imaging or treating colon adenocarcinoma. In vitro photodynamic therapy (PDT) studies have shown that both compounds are suitable and can be used in this field. Also, Es-SiPc has been shown to have higher phototoxicity than Es-SiPc-2. © 2020 World Scientific Publishing Company
Similar works
Full text
Available Versions
Ege University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:gcris.ege.edu.tr:11454/617...
Last time updated on 23/11/2023
Ege University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:gcris.ege.edu.tr:11454/700...
Last time updated on 23/11/2023