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First Human Experience with Directly Image-able Iodinated Embolization Microbeads
Authors
Victoria Anderson
Matthew R. Dreher
+12 more
Jean Francois H. Geschwind
Venkatesh P. Krishnasamy
Elliot B. Levy
Andrew L. Lewis
Chelsea Macfarlane
Andrew S. Mikhail
Ayele Negussie
Alessandro Radaelli
Karun V. Sharma
Imramsjah M.J. van der Bom
Sean Willis
Bradford J. Wood
Publication date
1 August 2016
Publisher
Health Sciences Research Commons
Abstract
© 2016, Springer Science+Business Media New York (outside the USA) and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). Purpose: To describe first clinical experience with a directly image-able, inherently radio-opaque microspherical embolic agent for transarterial embolization of liver tumors. Methodology: LC Bead LUMI™ is a new product based upon sulfonate-modified polyvinyl alcohol hydrogel microbeads with covalently bound iodine (~260 mg I/ml). 70–150 μ LC Bead LUMI™ iodinated microbeads were injected selectively via a 2.8 Fr microcatheter to near complete flow stasis into hepatic arteries in three patients with hepatocellular carcinoma, carcinoid, or neuroendocrine tumor. A custom imaging platform tuned for LC LUMI™ microbead conspicuity using a cone beam CT (CBCT)/angiographic C-arm system (Allura Clarity FD20, Philips) was used along with CBCT embolization treatment planning software (EmboGuide, Philips). Results: LC Bead LUMI™ image-able microbeads were easily delivered and monitored during the procedure using fluoroscopy, single-shot radiography (SSD), digital subtraction angiography (DSA), dual-phase enhanced and unenhanced CBCT, and unenhanced conventional CT obtained 48 h after the procedure. Intra-procedural imaging demonstrated tumor at risk for potential under-treatment, defined as paucity of image-able microbeads within a portion of the tumor which was confirmed at 48 h CT imaging. Fusion of pre- and post-embolization CBCT identified vessels without beads that corresponded to enhancing tumor tissue in the same location on follow-up imaging (48 h post). Conclusion: LC Bead LUMI™ image-able microbeads provide real-time feedback and geographic localization of treatment in real time during treatment. The distribution and density of image-able beads within a tumor need further evaluation as an additional endpoint for embolization
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Last time updated on 03/12/2020