CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Growth characteristics in individuals with osteogenesis imperfecta in North America: results from a multicenter study
Authors
Sunil Bellur
Michael B. Bober
+23 more
Peter H. Byers
David Cuthbertson
Michaela Durigova
David R. Eyre
Francis H. Glorieux
Tracy Hart
Mahim Jain
Deborah Krakow
Jeff Krischer
Brendan Lee
Mary Mullins
Sandesh C.S. Nagamani
Eric S. Orwoll
Melanie Pepin
Cathleen L. Raggio
Frank Rauch
Eric T. Rush
Jay R. Shapiro
Peter A. Smith
Robert D. Steiner
V. Reid Sutton
Allison Tam
Laura Tosi
Publication date
1 February 2019
Publisher
Health Sciences Research Commons
Abstract
© 2018, American College of Medical Genetics and Genomics. Purpose: Osteogenesis imperfecta (OI) predisposes people to recurrent fractures, bone deformities, and short stature. There is a lack of large-scale systematic studies that have investigated growth parameters in OI. Methods: Using data from the Linked Clinical Research Centers, we compared height, growth velocity, weight, and body mass index (BMI) in 552 individuals with OI. Height, weight, and BMI were plotted on Centers for Disease Control and Prevention normative curves. Results: In children, the median z-scores for height in OI types I, III, and IV were −0.66, −6.91, and −2.79, respectively. Growth velocity was diminished in OI types III and IV. The median z-score for weight in children with OI type III was −4.55. The median z-scores for BMI in children with OI types I, III, and IV were 0.10, 0.91, and 0.67, respectively. Generalized linear model analyses demonstrated that the height z-score was positively correlated with the severity of the OI subtype (P \u3c 0.001), age, bisphosphonate use, and rodding (P \u3c 0.05). Conclusion: From the largest cohort of individuals with OI, we provide median values for height, weight, and BMI z-scores that can aid the evaluation of overall growth in the clinic setting. This study is an important first step in the generation of OI-specific growth curves
Similar works
Full text
Available Versions
George Washington University: Health Sciences Research Commons (HSRC)
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:hsrc.himmelfarb.gwu.edu:sm...
Last time updated on 03/12/2020