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SLC30A8 nonsynonymous Variant is associated with recovery following exercise and skeletal muscle size and strength
Authors
Kasra Adham
Theodore J. Angelopoulos
+19 more
Priscilla M. Clarkson
Joseph M. Devaney
Heather Gordish-Dressman
Paul M. Gordon
Eric P. Hoffman
Monica J. Hubal
Amy K. Kearns
Justin S. Larkin
Jason S. Lipof
Stephanie Moeckel-Cole
Niall M. Moyna
E. Funda Orkunoglu-Suer
Ronak R. Patel
Linda S. Pescatello
Courtney Sprouse
Paul D. Thompson
Laura L. Tosi
Paul S. Visich
Robert F. Zoeller
Publication date
1 January 2014
Publisher
Health Sciences Research Commons
Abstract
Genome-wide association studies have identified thousands of variants that are associated with numerous phenotypes. One such variant, rs13266634, a nonsynonymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with a 53% increase in the risk of developing type 2 diabetes (T2D). We hypothesized that individuals with the protective allele against T2D would show a positive response to short-term and long-term resistance exercise. Two cohorts of young adults-the Eccentric Muscle Damage (EMD; n = 156) cohort and the Functional Single Nucleotide Polymorphisms Associated with Muscle Size and Strength Study (FAMuSS; n = 874)-were tested for association of the rs13266634 variant with measures of skeletal muscle response to resistance exercise. Our results were sexually dimorphic in both cohorts. Men in the EMD study with two copies of the protective allele showed less post-exercise bout strength loss, less soreness, and lower creatine kinase values. In addition, men in the FAMuSS, homozygous for the protective allele, showed higher pre-exercise strength and larger arm skeletal muscle volume, but did not show a significant difference in skeletal muscle hypertrophy or strength with resistance training. © 2014 by the American Diabetes Association
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George Washington University: Health Sciences Research Commons (HSRC)
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oai:hsrc.himmelfarb.gwu.edu:sm...
Last time updated on 03/12/2020
George Washington University: Health Sciences Research Commons (HSRC)
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:hsrc.himmelfarb.gwu.edu:sm...
Last time updated on 03/12/2020