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Proportion of estrogen or progesterone receptor expressing cells in breast cancers and response to endocrine therapy
Authors
Futoshi Akiyama
Naoko Honma
+5 more
Rie Horii
Yoshinori Ito
Takuji Iwase
Shigehira Saji
Mamoun Younes
Publication date
1 December 2014
Publisher
Health Sciences Research Commons
Abstract
© 2014 Elsevier Ltd. Immunohistochemical determination of ER/PR status has been the gold standard in clinical practice of breast cancer for decades. A cut-off of \u271%\u27 is commonly used; however, this is not supported by strict evidence. How the proportion of ER/PR-positive cells influences the response to endocrine therapy has been scarcely reported, either. To address these issues, 486 and 663 invasive breast cancer cases treated with or without adjuvant tamoxifen respectively (median follow-up period, 12.8 years) were enrolled, and effect of tamoxifen treatment was compared among ER/PR-positive or -negative groups immunohistochemically determined using various cut-offs. Tamoxifen significantly improved 5 years disease-free survival in ER/PR-positive, but not in ER/PR-negative, cases even using immunohistochemical \u3e0% cut-off. Cases with ≥67% ER/PR expressing cells responded to tamoxifen by far the best. Patients having tumors without any ER/PR-positive cells should be excluded from endocrine therapy, whereas this therapy should be strongly recommended for those with ≥67% ER/PR-positive cells
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George Washington University: Health Sciences Research Commons (HSRC)
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Last time updated on 03/12/2020