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Surgical therapy for biliary dyskinesia: A meta-analysis and review of the literature
Authors
Fredrick Brody
Robert DeSagun
Todd A. Ponsky
Publication date
1 October 2005
Publisher
Health Sciences Research Commons
Abstract
Background: Although biliary dyskinesia is treated commonly with cholecystectomy, the supporting literature is limited. A review and meta-analysis of the literature were performed to assess the efficacy of surgical therapy for biliary dyskinesia. Materials and Methods: A MEDLINE search for the period 1965 to 2003, using the search strings biliary, acalculous, dyskinesia, cholecystitis, cholecystectomy, and therapy returned 187 articles. Inclusion criteria required a study design that placed patients with biliary dyskinesia into one of two treatment groups, cholecystectomy or nonoperative therapy, and a follow-up assessment of symptomatic improvement. Results: Five studies met the inclusion criteria, representing a total of 274 patients. Surgical therapy resulted in 98% symptomatic relief compared to 32% with nonoperative management (P \u3c 0.0001). Patients undergoing surgical therapy for biliary dyskinesia were 2.79 times more likely to have symptomatic relief versus nonoperative therapy (95% confidence interval, 2.05-3.79). Conclusion: Based on this meta-analysis, cholecystectomy for biliary dyskinesia is an effective therapy and offers significant symptomatic relief over nonoperative therapy. © Mary Ann Liebert, Inc
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George Washington University: Health Sciences Research Commons (HSRC)
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Last time updated on 03/12/2020