CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
The effects of gold nanoparticles characteristics and laser irradiation conditions on spatiotemporal temperature pattern of an agar phantom: A simulation and MR thermometry study
Authors
A. Abbasian Ardakani
M. Asadi
+6 more
B. Ghalandari
S.K. Kamrava
A. Komeili
A. Shakeri-Zadeh
M. Zabanran
A. Zare-Sadeghi
Publication date
1 January 2020
Publisher
Abstract
In this paper, the effects of parameters related to gold nanoparticles (type, size, and concentration) and the laser parameters on spatiotemporal temperature pattern of an agar phantom during a photothermal therapy (PTT) procedure were modeled and then experimentally verified. Eight agar phantoms loaded by gold nanoparticles were made. An agar phantom without any nanoparticles was also considered as the control. Different sizes of two types of gold nanoparticles (spherical and silica-gold core shell) at various concentrations were studied. The phantoms were irradiated by various laser powers for 5 min. The temperature changes in each phantom was firstly calculated using COMSOL Multiphysics software. Also, each phantom was irradiated by laser and MR thermometry was performed to validate the simulation results. A reasonable correlation between simulation and MR thermometry was obtained (R = 0.92). The error interval between calculations and experiments was ranged from ±3 to ±6. It was clearly evident that laser irradiation conditions and nanoparticle characteristics affected the temperature rise profile. Spherical 20 nm gold nanoparticles had better thermal efficiency and generated higher level of heat. The protocol suggested in this study may be appropriate to make a pre-clinical calculation and effect visualization for any nanoparticles-based PTT procedure before entrance into the clinics. © 2019 Elsevier Gmb
Similar works
Full text
Available Versions
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:24123
Last time updated on 01/12/2020