The effect of colchicine on the echocardiographic constrictive physiology after coronary artery bypass graft surgery

Abstract

Background: Constrictive physiology is a transitory condition that could lead to constrictive pericarditis, which is a rare complication after open-heart surgery. Anti-inflammatory drugs like colchicine are recommended for prevention of constrictive pericarditis; however, there is no evidence about the effect of colchicine on constrictive pericarditis. Thus, the aim of this study is to evaluate the preventive effect of colchicine on the incidence of echocardiographic constrictive physiology after open-heart surgery. Methods: This was a parallel randomized, double-blind trial. Patients were randomly assigned to receive 1 mg colchicine once-daily from 48 hours before and 0.5 mg twice daily for 5 days after surgery. Primary outcome was the incidence of the constrictive physiology after primary endpoint (1 week after the surgery). The secondary outcome was the primary outcome after secondary endpoint (4 weeks after surgery) plus the new cases of constrictive physiology between the primary and secondary endpoints. Results: Out of 160 participating patients, the primary outcome occurred in 19 patients (23) in placebo and 11 (13) in intervention groups. There was no significant difference between two groups (P =.106). After 4 weeks of follow-up, 19 patients (23) in placebo and 9 (11) in intervention groups had constrictive physiology whereas 2 out of 11 patients (18.2) were recovered. The difference was significant (P =.038). No new case of constrictive physiology occurred between primary and secondary endpoints. Conclusion: Short-term use of colchicine has a preventive effect on reducing constrictive physiology after 1 month of open-heart surgery but not a week after that. © 2020 Wiley Periodicals, Inc