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The Effect of Demographic Factors and VKORC1 1639 G>A Genotypes on Estimated Warfarin Maintenance Dose in Iranian Patients Under Warfarin Therapy
Authors
A. Dorgalaleh
M. Hamidpour
B. Poopak
F. Rad
Publication date
1 January 2019
Publisher
Abstract
Warfarin is an anticoagulant that inhibits vitamin K-dependent clotting factors including factor (F) II, FVII, FIX and FX. Different factors can change the effect of this anticoagulant in clinic. Therefore we assessed impact of VKORC1 -1639 G>A polymorphism and demographic factors on required maintenance dose in Iranian patients under warfarin therapy. The study population included 95 patients with a mean age of 61.3 ± 12.6 years. Target INR range of 2�3 was considered for these patients. The frequency of VKORC1 -1639 G>A polymorphism was assessed by polymerase chain reaction-restriction length polymorphism (PCR-RFLP). Finally the obtain data were analyzed by SPSS software. Our study revealed that 30.5, 49.5, and 20 of the patients had VKORC1 (G/G), (G/A), and (A/A) genotypes, respectively. Carriers of VKORC1 G/G genotype required a higher warfarin dose as compared to A/A carriers (4.48 ± 1.32 and 2.7 ± 1.16 mg/day, respectively; P A polymorphism and demographic variables had significant effects on warfarin maintenance dose in Iranian patients under warfarin therapy. © 2018, Indian Society of Hematology and Blood Transfusion
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:15082
Last time updated on 01/12/2020