Gonzalez-Castellon, Marco A.

Hariharan, Praveen

Phipps, Connor J.

Warren, David E.

English

University of Nebraska Medical Center Research: DigitalCommons@UNMC

Graduate Medical Education Research Journal Volume 2 Issue 1 Article 53 September 2020 Functional MRI Changes in Ischemic Stroke Patients Following Mechanical Thrombectomy Praveen Hariharan et al. Follow this and additional works at: https://digitalcommons.unmc.edu/gmerj  Part of the Higher Education Commons, and the Medicine and Health Sciences Commons Recommended Citation Hariharan, P. Functional MRI Changes in Ischemic Stroke Patients Following Mechanical Thrombectomy. Graduate Medical Education Research Journal. 2020 Sep 29; 2(1). https://digitalcommons.unmc.edu/gmerj/vol2/iss1/53 This Conference Proceeding is brought to you for free and open access by DigitalCommons@UNMC. It has been accepted for inclusion in Graduate Medical Education Research Journal by an authorized editor of DigitalCommons@UNMC. For more information, please contact digitalcommons@unmc.edu. Functional MRI Changes in Ischemic Stroke Patients Following Mechanical Thrombectomy Creative Commons License This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License. This conference proceeding is available in Graduate Medical Education Research Journal: https://digitalcommons.unmc.edu/gmerj/vol2/iss1/53 Sept. 2020  |  Vol. 2  |  Issue 1 Poster Presentations 49*Names in bold type indicate presenting author.In-Hospital Medication Delivery in Status Epilepticus: Targeting the Delays in Drug Dispensing and Administration Navnika Gupta1, Hae Y. Baang1, Nicholas Swingle , Katharine Reisbig2, Kayli A. Bendlin2, Scott A. Coleman2, Kelly R. Goetschkes1, Olga Taraschenko11University of Nebraska Medical Center, Department of Neurological Sciences 2University of Nebraska Medical Center, College of PharmacyMentor: Olga TaraschenkoProgram: Neurological SciencesType: Original ResearchBackground: We have previously shown 	third order medications for nonconvulsive status epilepticus (NCSE) was delayed at the University of Nebraska Medical Center (UNMC), a level 4 epilepsy center. We established that the delay in medication delivery was caused by untimely recognition of seizures and prolonged medication order processing. To overcome the latter barrier and streamline the completion of medication 			delays within the inpatient pharmacy. We also engaged pharmacy managers to provide staff education and support the placement of commonly used anticonvulsants in the Omnicell medication dispensing system on 	Methods: We implemented the Omnicell medication dispensing system for the use of intravenous levetiracetam (LEV) and 	!introduced SE order set and SE response protocol. Retrospective and prospective chart analysis was performed to compare the times from the order to administration of all anticonvulsants following the implementation of these measures with the corresponding times during the preceding three-year period for all patients with NCSE; the anesthetic medications were excluded.Results: A total of 77 and 38 orders for the 		for NCSE were placed prior to and following 		"#		!system, respectively. Of them, intravenous LEV and LCM were ordered in 24 (31.2%) and 14 (36.8%) of instances prior to and after the improvement, respectively; the proportions of these orders were similar in two groups (p=0.54; Pearson’s chi-squared test). The median latencies to the administration of all anticonvulsants prior and following the implementation of the Omnicell system were 34 (IQR 18-58) and 21 min (IQR 12-45), respectively (p=0.18, Mann-Whitney test). The median time to the administration of LEV and LCM have decreased from 57 (IQR 41-99) to 42 min (IQR 31-105) after the introduction of the Omnicell dispensing system and staff education (p=0.41; Mann-Whitney test).Conclusion: The delivery of treatment for NCSE may be streamlined by the education of pharmacy staff and closer proximity of the medications commonly used in acute seizure emergencies to the patients’ bedside. To further improve the effectiveness of care for patients with NCSE, we provided the education to the fellows from the Critical Care services and plan to implement an educational course for nurses from neurology 			https://doi.org/10.32873/unmc.dc.gmerj.2.1.050Functional MRI Changes in Ischemic Stroke Patients Following Mechanical Thrombectomy Praveen Hariharan1, Marco A. Gonzalez-Castellon1, Connor J. Phipps1, David E. Warren11University of Nebraska Medical Center, Department of Neurological SciencesMentor: Marco A. Gonzalez-CastellonProgram: Neurological SciencesType: Original ResearchBackground: Recent evidence in stroke research suggests that functional connectivity measures such as modularity assessed by resting state functional MRI (rs-fMRI) may provide insights in predicting prognosis and may help characterize outcome differences associated with mechanical thrombectomy (MT). We measured brain network modularity longitudinally in MT-treated ischemic stroke patients.Methods: This study was approved by Institutional Review Board at the University of Nebraska Medical Center. MT-treated stroke patients were recruited. A 3T Siemens Prisma MRI scanner was used to collect data with a protocol adapted from the Human Connectome Project (HCP). The protocol included structural measures as well as  rs-fMRI measures (multiband EPI). Images $			&three months after stroke. rs-fMRI data were processed with HCP pipelines. Network modularity was measured using a previously reported cortical parcellation.Results: We recruited three patients (1F/2M; mean age=56 years). Average NIHSS was 11. Two were treated with IV thrombolysis plus MT and one was treated with MT. Two &	!				'the other was subcortical. Mean door-to-needle time was 35 min.; mean reperfusion time was 201 min. Modularity measures showed that patients with cortical infarcts exhibited increased modularity between time points, while the subcortical infarct exhibited decreased modularity.Conclusion: Increases in brain network modularity over time in two out of three *"		or reorganization of brain networks to support normal brain function. Longitudinal cohort studies of stroke could help us better understand functional brain network disruption, track recovery, guide stroke interventions, and improve prognostication. https://doi.org/10.32873/unmc.dc.gmerj.2.1.051

Functional MRI Changes in Ischemic Stroke Patients Following Mechanical Thrombectomy

https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1148&amp;context=gmerj

Functional MRI Changes in Ischemic Stroke Patients Following Mechanical Thrombectomy

Abstract

Similar works

Full text

Available Versions

University of Nebraska Medical Center Research: DigitalCommons@UNMC