With increasing healthcare-associated infections and antibiotic-resistant microorganisms there is a demand not
only for new antimicrobial compounds but also for antimicrobial materials. With the use of synthetic protein
biotechnology approaches and recombinant DNA technology, we can now create new tailor-made materials with
precise control over its sequence. Indeed, by combining antimicrobial activity of naturally occurring antimicrobial
peptides (AMPs) with recombinant protein-based polymers, such as elastin-like recombinamers (ELRs), it is
possible to create novel materials that can be explored for the development of advanced antimicrobial medical
devices. In the present work, we have functionalized an ELR with AMPs for the development of biopolymers with antimicrobial activity. The antimicrobial ELRs were designed by cloning the DNA sequence coding for d
