Wet-spinning is a non-solvent induced phase inversion technique that allows the
production of continuous polymeric microfibers, with a uniform morphology, based on the
principle of precipitation. It allows the production of 3D fibrous constructs with an intricated
architecture that facilitates cell infiltration, something that is very limited in electrospun
nanofibrous mats, thus increasing its interest in biomedicine. Wet-spun scaffolds are also more
easily processed and can be loaded with a variety of biomolecules of interest. Antimicrobial
agents that display a broad spectrum of activity against bacteria, fungi and viruses have been
combined with such constructs demonstrating great potential to fight infections. In the present
work, we explore the use of wet-spinning to process both natural and synthetic biodegradable
polymers in the form of microfibers, and the necessary processes to modify their surface to
increase their antimicrobial profile. The synergistic potential of specialized biomolecules within
wet-spun fibrous architectures are also highlighted.Authors acknowledge the Foundation for Science and Technology (FCT) of Portugal for funding the
projects PTDC/CTM-TEX/28074/2017 (POCI-01-0145-FEDER-028074) and UID/CTM/00264/2020
from 2C2T
