This work is devoted to the study of the non-perturbative contributions in
non-leptonic hyperon decays. We show that the instanton-induced 't Hooft
interaction can naturally explain the Delta I=1/2 rule, by generating
quark-diquark clustering inside octet baryons. We compute P-wave and S-wave
amplitudes in the Instanton Liquid Model (ILM), and find good agreement with
experiment. We propose a model-independent procedure to test on the lattice if
the leading quark-quark attraction in the 0^+ anti-triplet channel responsible
for diquark structures in hadrons is originated by the interaction generated by
quasi-classical fields or it is predominantly due to other perturbative and/or
confining forces.Comment: Final version to appear on PR