This research investigated the effect of gender and clinical self-efficacy on professional competence among health workers in Ekiti State. A cross-sectional survey design was used for the study. A sample of 246 community health workers across twenty four hospitals in Ekiti State was sampled using questionnaire. It comprised different cadres of community health workers. Three research hypotheses were generated in line with the study objectives. 2 X 2 ANOVA was used to test the main and interaction effects of gender and clinical self-efficacy on professional competency of the participants. Result indicated that clinical self-efficacy had significant main effect on professional competency of the participants [F (1, 245) = 5.716; P <. 05]. However, gender did not have significant main effect on professional competency of the participants. Results showed that there was no significant interaction effect of gender and clinical self-efficacy on professional competency of the community health workers in Ekiti State. The findings were discussed in line with other related works and it was recommended that urgent intervention strategies by policy makers to help community health workers develop the capacity for efficiency and feedback, in enhancing their success in their professional practices should be put in place
