Nanoparticles exhibited exceptional properties for drug delivery via
different routes with excellent pharmacokinetics profiles using
minimal dosages with almost no systemic side effects. The delivery
of drug molecules for therapeutic applications usually faces problems
of solubility and bioavailability that cubosomes can easily overcome.
Cubosomes are cubic lipid-based nanoparticles with increased
surface area, low viscosity and high heat stability. The preparation of
cubosomes and drug encapsulation are still procedures requiring
important improvements that have limit their use as drug delivery
system. This work we developed a simple experimental procedure
able to produce controlled-size cubosomes with different
hydrodynamic size dependent of the phytantriol/ethanol
(lipid/hydrotrope) ratio. Moreover, cubosomes were easily loaded
with ciprofloxacin without structural changes. The results of this
study will greatly impact on the applicability of cubosomes as drug
delivery system.info:eu-repo/semantics/publishedVersio
