Article in pressAge related neurodegenerative disorders (ARND) are presented as the most debilitating and challenging diseases
associated with the central nervous system. Despite the advent of active molecules with a positive role on
neurodegenerative mechanisms, many of the current therapeutic strategies remain ineffective in treating or
preventing ARND. Lipid nanocarriers have emerged as efficient delivery systems with the capability to cross
biological barriers, especially the blood brain barrier (BBB). Also, when associated to natural compounds, lipid
nanocarriers have demonstrated to be an interesting alternative to ARND therapies with multiple beneficial
effects. This comprehensive review focus on state-of-the-art lipid based nanocarriers for the delivery of natural
compounds targeting neurodegeneration. A critical analysis of published reports will be also provided giving
indications to researchers about the most promising ARND nanotherapy strategies.Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013. Marlene Lúcio acknowledges the exploratory project funded by FCT with the reference IF/00498/2012. Telma Soares acknowledges COMPETE 2020 “Programa Operacional Competitividade e internacionalização”info:eu-repo/semantics/publishedVersio