Bone morphogenetic proteins have promoted great
biomedical interest due to their ability in inducing
new bone formation when used as powerful
osteoinductive components of several late-stage
bone grafting products. Recombinant human bone
morphogenetic protein-2 (rhBMP-2) is obtained from
mammalian cell expressing systems in low amounts
or from bacteria inclusion bodies after timeconsuming
refolding methods. Thus, there is a need
to establish novel approaches for producing rhBMP-2
in high yields by simple and cheap procedures.Portuguese Foundation for Science and Technolog
y, FCT (PhD Grant to PC
Bessa
, SFRH/BD/17049/2004). This work was also partially supported
by the European STREP HIPPOCRATES (NMP3
-
CT
-
2003
-
505758) and carried out under the scope of European
NoE
EXPERTISSUES (NMP3
-
CT
-
2004
-
500283).info:eu-repo/semantics/publishedVersio