We report the results of angular-dependent ac susceptibility experiments performed on two derivatives of Mn12 single-molecular magnets: the well-known Mn12 acetate, which contains disordered acetic acid molecules in interstitial sites of the crystal structure and Mn12-tBuAc, for which solvent molecules are very well ordered in the structure. Our results show (a) that the angular variation is very similar in the two compounds investigated and compatible with a maximum misalignment of the anisotropy axes of less than 3° and (b) that the tunneling rate is faster for the better ordered Mn12-tBuAc compound. These experiments question interstitial disorder as the dominant origin of the thermally activated tunneling phenomenon