Este resumo faz parte de: Book of abstracts of the Meeting of the Institute for Biotechnology and Bioengineering, 2, Braga, Portugal, 2010. A versão completa do livro de atas está disponível em: http://hdl.handle.net/1822/1096

Avides, Maria do Carmo

Martinho, Olga Catarina Lopes

Reis, R. M.

Universidade do Minho: RepositoriUM

2ND SCIENTIFIC MEETING OF THE INSTITUTE FOR BIOTECHNOLOGY AND BIOENGINEERING  Braga, 23‐24 October 2010 CENTRE OF BIOLOGICAL ENGINEERING UNIVERS IDADE  DO  MINHO 148    ASPM is an oncoprotein and activates EGFR  Martinho, Olga2; Reis, Rui2; and Maria do Carmo Avides1  1IBB-Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal  2ICVS, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal   ASPM is a protein required for the correct assembly and function of microtubule spindles. It participates in human brain development as well and is overexpressed in all tumours studied so far. We are interested in further characterizing ASPM function as it is unclear why it affects brain growth and is related to cancer. This prompted us to isolate ASPM-binding proteins. We found that EGFR (Epidermal Growth Factor Receptor), a protein highly involved in cancer, would bind ASPM. Furthermore, ASPM promotes activation of EGFR by phosphorylation resulting in a more active MAP kinase pathway. Our findings explain the involvement of ASPM in cancer, set ASPM as a new therapeutic target, and demonstrate a novel activity of the protein not related to mitosis.    [1] Encarnação JM, Stallinga P, Ferreira GNM, “Influence of electrolytes in the QCM response: Discrimination and quantification of the interference to correct microgravimetric data”, Biosens. Bioel. (2007) 22:1351-1358.  

ASPM is an oncoprotein and activates EGFR

http://repositorium.sdum.uminho.pt/bitstream/1822/28310/1/Pages%20from%20Book_of_Abstracts-6.pdf

ASPM is an oncoprotein and activates EGFR

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