This study describes the development of a workflow for integrated life-cycle assessment (iLCA) of buildings that is capable of capturing the dependencies between multi-hazard resilience and sustainability using tools native to professional practice. Modules dedicated to hazard characterization, structural response, damage, repair/loss, and environmental impact (embodied and operating energy) are developed using Application Programming Interfaces (APIs) and semantic data perspectives from computer science. A unifying probabilistic framework is utilized to quantify life-cycle performance and a common, versatile, simulation-based approach is adopted for estimation of performance. This approach supports various resilience/sustainability metrics, including monetary losses, downtime, total embodied energy (initial construction and repairs), and operating energy. A case study executed in the Revit environment evaluates the performance of a special reinforced concrete frame located near Los Angeles International Airport (LAX). Two design alternatives are considered to illustrate the impact of design and material decisions, ultimately revealing design choices which best achieve joint resiliency and sustainability.The authors gratefully acknowledge the support of NSF (CMMI-1537652). The first author also recognizes the support of her NSF Graduate Research Fellowship (DGE-1313583) and Deans Fellowship from the University of Notre Dame. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of NSF