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Piezoelectric Materials Based Scaffolds Fabrication for Cardiamyocyets Cell Growth

Abstract

Tissue engineering is concerned on the growth of tissue making organs for implantation back to the donor himself. Instead of using organs transplantation and expose the patient for immunological rejection possibility, implantation is another alternative approach. Artificial scaffolds have to be fabricated base on the targeted organ. The projected scaffolds should have designed shapes with a suitable mechanical toughness, wettability, porosity, biodegradability and biocompatibility. Ideally, the projected scaffold should also allow imitating of the normal cell microenvironment in order to produce a tissue with the same biological functions as found in a body. Cardiomyocytes or cardiac myocytes required specific type of scaffold and in this work we developed a pattern of polyvinylidene fluoride (PVDF), a piezoelectric, fluoropolymer, and a highly non-reactive using electro spinning to form a nanoscale fibers from a liquid as a concept of energy harvesting from heart beating using piezoelectric material. Three different polymer solutions were made using 15%, 12% and 10% of PVDF each in DMF under specific condition and quantities. The second part of this experimental work is to fabricate the PVDF nanofibers from polymer solutions in the presence of conductive graphene nanoplateletes under specific condition and quantities. All produced nanofibers will be characterized and compared using X-ray diffraction (XRD), Electrochemical Impedance Spectroscopy (EIS) and Dynamic Mechanical Analyzer (DMA) for choosing optimal fibers

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