Introduction: Cardiovascular diseases are the most important cause of mortality in the world. In addition to physical problems, they are also influenced by psychological factors and psychological therapies along with biological therapy can help to improve these patients. The purpose of this study was to compare the effectiveness of acceptance and commitment therapy and emotion-focused therapy on negative emotions of coronary heart disease patients.Method: This was a quasi-experimental study with pretest-posttest design with control group. The statistical population of the study included patients with coronary heart disease in the city of Karaj The age range was 30 to 60 yearswho referred to Shahid Rajaee Hospital in Karaj. Samples were selected using available sampling method and then the samples were randomly divided into two experimental and one control group. Data were collected using D-type personality scale and Buss and Perry hostility scale.Data were analyzed by descriptive statistics and analysis of covariance using SPSS-25 software.Results: The results of this study showed that patients' negative emotion scale scores decreased, indicating the effectiveness of acceptance and commitment therapy and emotion-focused therapy compared to the control group. Conclusion: Considering that one of the most important psychological factors related to heart disease are negative emotions and these emotions can have an accelerating role in the development and progression of heart disease and Due to the effectiveness of the above treatments, their education can be helpful in addition to medical treatment