Striking Difference between Succinimidomethyl and Phthalimidomethyl Radicals in Conjugate Addition to Alkylidenemalonate Initiated by Dimethylzinc

Abstract

We used dimethylzinc to develop a conjugate addition reaction of imidomethyl radicals to alkylidenemalonates using dimethylzinc, in which we observed a significant difference between succinimidomethyl and phthalimidomethyl radicals. This reaction provides new access to γ- aminobutyric acid derivatives, which often function as neurotransmitters

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