Recent conceptual, algorithmic and technical advances allow numerical
simulations of lattice QCD with Wilson quarks to be performed at significantly
smaller quark masses than was possible before. Here we report on simulations of
two-flavour QCD at sea-quark masses from slightly above to approximately 1/4 of
the strange-quark mass, on lattices with up to 64x32^3 points and spacings from
0.05 to 0.08 fm. Physical sea-quark effects are clearly seen on these lattices,
while the lattice effects appear to be quite small, even without O(a)
improvement. A striking result is that the dependence of the pion mass on the
sea-quark mass is accurately described by leading-order chiral perturbation
theory up to meson masses of about 500 MeV.Comment: TeX source, 17 pages, figures include