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Therapeutic Potential of Berberine in the Treatment of Glioma: Insights into Its Regulatory Mechanisms
Authors
Z. Asemi
M. Behnam
+4 more
H. Mirzaei
M.A. Pourattar
Z.S. Razavi
O.R. Tamtaji
Publication date
1 January 2020
Publisher
'Springer Fachmedien Wiesbaden GmbH'
Abstract
Glioma is known as one of the most common primary intracranial tumors accounting for four-fifths of malignant brain tumors. There are several biological pathways that play a synergistic, pathophysiological role in glioma, including apoptosis, autophagy, oxidative stress, and cell cycle arrest. According to previous rese arches, the drugs used in the treatment of glioma have been associated with significant limitations. Therefore, improved and/or new therapeutic platforms are required. In this regard, multiple flavonoids and alkaloids have been extensively studied in the treatment of glioma. Berberine is a protoberberine alkaloid with wide range of pharmacological activities, applicable to various pathological conditions. Few studies have reported beneficial roles of berberine in glioma. Berberine exerts its pharmacological functions in glioma by controlling different molecular and cellular pathways. We reviewed the existing knowledge supporting the use of berberine in the treatment of glioma and its effects on molecular and cellular mechanisms. © 2020, Springer Science+Business Media, LLC, part of Springer Nature
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:39106
Last time updated on 11/10/2021
kashan university of medical sciences
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oai:eprints.kaums.ac.ir:5565
Last time updated on 25/11/2020