'Blavatnik School of Government, University of Oxford'
Abstract
Previous work has demonstrated the potential of magnetically functionalized microbubbles to localize and enhance cavitation activity under focused ultrasound exposure in vitro. The aim of this study was to investigate magnetic targeting of microbubbles for promotion of cavitation in vivo. Fluorescently labelled magnetic microbubbles were administered intravenously in a murine xenograft model. Cavitation was induced using a 0.5 MHz focused ultrasound transducer at peak negative focal pressures of 1.2-2.0 MPa and monitored in real-time using B-mode imaging and passive acoustic mapping. Magnetic targeting was found to increase the amplitude of the cavitation signal by approximately 50% as compared with untargeted bubbles. Post-exposure magnetic resonance imaging indicated deposition of magnetic nanoparticles in tumours. Magnetic targeting was similarly associated with increased fluorescence intensity in the tumours following the experiments. These results suggest that magnetic targeting could be used to improve delivery of cavitation-mediated therapy and that passive acoustic mapping could be used for real-time monitoring of this process. This dataset includes processed experimental data for the paper ‘Enhancement and passive acoustic mapping of cavitation from fluorescently-tagged MR-visible magnetic microbubbles in vivo’, accepted for publication in Ultrasound in Medicine and Biology in August 2016.
The data is organised in the order of the figures in the paper and includes:
Fig 1: TIFF figure and SVG source file, TXT caption
Fig 2: TIFF images, CSV data and Matlab FIG files, TXT caption
Fig 3: TIFF and Matlab FIG files, TXT caption
Fig 4: TIFF image and CSV data files, TXT caption
Fig 5: TIFF images and Matlab FIG files, TXT caption
Fig 6: TIFF images, Matlab FIG files and CSV data file, TXT caption
Fig 7: CSV data file, TXT caption
Fig 8: TIFF and PNG images and CSV data file, TXT caption
Data were gathered using microscopy, ultrasound and MRI techniques described in detail in the paper
