The destructive power of tropical cyclones is driven by latent heat released from water condensation and is inevitably linked to the abundance of aerosols as cloud condensation nuclei. However, the aerosol effects are unaccounted for in most operational hurricane forecast models. We combined multisource measurements and cloud‐resolving model simulations to show fundamentally altered cloud microphysical and thermodynamic processes by anthropogenic aerosols during Hurricane Harvey. Our observational analyses reveal intense lightning and precipitation in the proximity of Houston industrial areas, and these hot spots exhibit a striking geographic similarity to a climatological maximum of lightning flash density in the south‐central United States. Our ensemble cloud‐resolving simulations of Hurricane Harvey indicate that aerosols increase precipitation and lightning by a factor of 2 in the Houston urban area, unraveling the key anthropogenic factor in regulating flooding during this weather extreme
