High efficiency gene transfer to airways of mice using influenza hemagglutinin pseudotyped lentiviral vectors: HA pseudotyping of lentiviral vectors

Abstract

A limitation to efficient lentivirus-mediated airway gene transfer is the lack of receptors to commonly used viral envelopes on the luminal surface of airway epithelia. The use of viral envelopes with natural tropism to the airway could be useful for overcoming this limitation