Catalytic Asymmetric Cross-Couplings of Racemic α-Bromoketones with Arylzinc Reagents

Abstract

Nickel box : The first catalytic asymmetric method for cross‐coupling arylzinc reagents with α‐bromoketones has been developed (see scheme). This stereoconvergent carbon–carbon bond‐forming process occurs under unusually mild conditions and without activators, thereby allowing the generation of potentially labile tertiary stereocenters