Synthesis of 5-Isovaleryl-3,3-Dimethyl-1,2,4-Cyclopentanetrione, A Homologue of Tetrahydrohulupone

Abstract

3,3-Dimethyl-1,2,4-cyclopentanetrione is prepared in high yield by hydrolysis and debromination of the easily accessible 2,3,5,5-tetrabromo-4,4-dimethyl-2-cyclopentanone. Acylation with isovaleric anhydride affords the title compound