Blaizot, St\ue9phanie

Hens, Niel

Herzog, Sereina

Ho, Erwin

Hutse, Veronik

Jacques, Marjorie

Litzroth, Amber

Lizroth, Amber

Michielsen, Peter

Rahman, Abbas

Schenk, Julie

Suin, Vanessa

Theeten, Heidi

van Damme, Pierre

Van Gucht, Steven

Vanwolleghem, Thomas

Verburgh, Vera

Abstract: Recent European studies suggest an emergence of hepatitis E virus (HEV) infection. We evaluated trends in birth cohort\u2010specific HEV seroprevalence and regional differences in Belgium. HEV IgG seroprevalence was analysed on national serum banks (1579 and 2087 samples for 2006 and 2014 respectively. Hepatitis E virus antigen was tested on positive samples. Observed data were modelled using a generalized additive model with a complementary log\u2010log link . No significant differences between birth cohorts or sexes were found. Modelling identified the individual\u2019s age and province as relevant factors. The probability of HEV seropositivity increases significantly with age. An estimated total of 434,819 (yearly rate of 54,352) (sero\u2010)infections was found between 2006 and 2014. Overall HEV IgG seroprevalences were 4.1% (64/1579, 95% CI 3.1\u20105.1) and 5.8% (121/2087, CI 4.8\u20106.9) in 2006 and 2014; respectively. Observed HEV antigen seroprevalence was 0.027% (1/3666) for the entire cohort. These results show stable HEV IgG seroprevalence in Belgium

Institutional Repository Universiteit Antwerpen

Stable HEV IgG seroprevalence in Belgium between 2006-2014

Stable HEV IgG seroprevalence in Belgium between 2006-2014

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Institutional Repository Universiteit Antwerpen