Abramowicz, Daniel

Abrams, Steven

De Winter, Benedicte

Gielis, Els

Hellemans, Rachel

Hens, Niel

Hesselink, Dennis A.

Ledeganck, Kristien

Massart, Annick

Plaeke, Philip

Wijtvliet, Veerle

Abstract: A systematic review and meta\u2010analysis were performed to investigate the value of donor\u2010derived cell\u2010free DNA (dd\u2010cfDNA) as a noninvasive biomarker in diagnosing kidney allograft rejection. We searched PubMed, Web of Science and the Cochrane Library for original research papers published between January 1994 and May 2020 on dd\u2010cfDNA fractions in blood of kidney allograft recipients. A single\u2010group meta\u2010analysis was performed by computing pooled estimates for dd\u2010cfDNA fractions using the weighted median of medians or quantile estimation (QE) approach. Weighted median differences in medians (WMDMs) and median differences based on the QE method were used for pairwise comparisons. Despite heterogeneity among the selected studies, the meta\u2010analysis revealed significantly higher median dd\u2010cfDNA fractions in patients with antibody\u2010mediated rejection (ABMR) than patients without rejection or patients with stable graft function. When comparing patients with T cell\u2010mediated rejection (TCMR) and patients with ABMR, our two statistical approaches revealed conflicting results. Patients with TCMR did not have different median dd\u2010cfDNA fractions than patients without rejection or patients with stable graft function. dd\u2010cfDNA may be a useful marker for ABMR, but probably not for TCMR

Institutional Repository Universiteit Antwerpen

Donor\u2010derived cell\u2010free DNA as a biomarker for rejection after kidney transplantation : a systematic review and meta\u2010analysis

Donor\u2010derived cell\u2010free DNA as a biomarker for rejection after kidney transplantation : a systematic review and meta\u2010analysis

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Institutional Repository Universiteit Antwerpen