Corthouts, Bob

El Addouli, Haroun

Mebis, Wouter

Nicolay, Simon

op de Beeck, Bart

Snoeckx, Annemie

Spinhoven, Maarten

Van Hoyweghen, Astrid

Abstract: Background: The correlation of diffusion-weighted MRI and tumor aggressiveness has been established for different tumor types, which leads to the question if it could also apply for neuroendocrine tumors (NET). Purpose: To investigate the possible correlation between apparent diffusion coefficient (ADC) value on magnetic resonance imaging (MRI) and histopathologic WHO-grades of NET. Material and Methods: Electronic patient records from patients presented at the multidisciplinary neuro-endocrine tumor board between November 2017 and April 2019 were retrospectively reviewed. Patients with both available MR imaging (primary tumor or metastasis) and known WHO tumor grade were included (n = 47). Average and minimum ADC values (avgADC; minADC) were measured by drawing a freehand ROI excluding only the outermost border of the lesion. The largest axial size (primary tumor) or most clearly delineated lesion (metastasis) was used. Results: Forty seven patients met the inclusion criteria (mean age 59 +/- 12 SD; 24F/23M). Twenty one patients (45%) were diagnosed with WHO G1 tumor, 17 seventeen with G2 (36%) and nine with G3 (19%) tumor. Twenty eight primary tumors and 19 metastases were measured. A significant difference was found between low-grade (G1+G2) and high-grade (G3) tumors (Mann-Whitney; avgADC: p < 0,001; minADC: p = 0,001). There was a moderate negative correlation between WHO-grade and avgADC/minADC (Spearman; avgADC: -0,606; 95% CI [-0,773; -0,384]; minADC: -0,581; 95% CI [-0.759; -0.353]). Conclusion: Our data show a significant difference in both average and minimum ADC values on MRI between low and high grade NET. A moderate negative correlation was found between histopathologic WHO grade and ADC value

Institutional Repository Universiteit Antwerpen

Correlation between apparent diffusion coefficient value on MRI and histopathologic WHO grades of neuroendocrine tumors

Correlation between apparent diffusion coefficient value on MRI and histopathologic WHO grades of neuroendocrine tumors

Abstract

Similar works

Full text

Available Versions

Institutional Repository Universiteit Antwerpen