AR Bakhshayesh

AR Clarke

AS Kaufman

C Tye

CG Lim

Choon Guan Lim

CM MacLeod

Cuntai Guan

D Shaffer

Daniel Shuen Sheng Fung

E El-Sayed

E Mick

GJ Dupaul

H Gevensleben

Haihong Zhang

HN Logemann

J Abibullaev B An

J Biederman

JN Swartwood

K. Ranga Rama Krishnan

L Shalev

M Arns

M Beauregard

MB Sterman

N Lofthouse

NJ Steiner

RJ Barry

S Pliszka

SK Loo

SM Butnik

SM Snyder

Stephanie Sze Wei Teng

Tih Shih Lee

VJ Monastra

Yu-Feng Zang

Yudong Zhao

PLoS ONE

PubMed

Attention deficit hyperactivity disorder (ADHD) symptoms can be difficult to treat. We previously reported that a 20-session brain-computer interface (BCI) attention training programme improved ADHD symptoms. Here, we investigated a new more intensive BCI-based attention training game system on 20 unmedicated ADHD children (16 males, 4 females) with significant inattentive symptoms (combined and inattentive ADHD subtypes). This new system monitored attention through a head band with dry EEG sensors, which was used to drive a feed forward game. The system was calibrated for each user by measuring the EEG parameters during a Stroop task. Treatment consisted of an 8-week training comprising 24 sessions followed by 3 once-monthly booster training sessions. Following intervention, both parent-rated inattentive and hyperactive-impulsive symptoms on the ADHD Rating Scale showed significant improvement. At week 8, the mean improvement was -4.6 (5.9) and -4.7 (5.6) respectively for inattentive symptoms and hyperactive-impulsive symptoms (both p<0.01). Cohen's d effect size for inattentive symptoms was large at 0.78 at week 8 and 0.84 at week 24 (post-boosters). Further analysis showed that the change in the EEG based BCI ADHD severity measure correlated with the change ADHD Rating Scale scores. The BCI-based attention training game system is a potential new treatment for ADHD.ClinicalTrials.gov NCT01344044

K Ranga Rama Krishnan

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A brain-computer interface based attention training program for treating attention deficit hyperactivity disorder.

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A Brain-Computer Interface Based Attention Training Program for Treating Attention Deficit Hyperactivity Disorder

<div><p>Attention deficit hyperactivity disorder (ADHD) symptoms can be difficult to treat. We previously reported that a 20-session brain-computer interface (BCI) attention training programme improved ADHD symptoms. Here, we investigated a new more intensive BCI-based attention training game system on 20 unmedicated ADHD children (16 males, 4 females) with significant inattentive symptoms (combined and inattentive ADHD subtypes). This new system monitored attention through a head band with dry EEG sensors, which was used to drive a feed forward game. The system was calibrated for each user by measuring the EEG parameters during a Stroop task. Treatment consisted of an 8-week training comprising 24 sessions followed by 3 once-monthly booster training sessions. Following intervention, both parent-rated inattentive and hyperactive-impulsive symptoms on the ADHD Rating Scale showed significant improvement. At week 8, the mean improvement was −4.6 (5.9) and −4.7 (5.6) respectively for inattentive symptoms and hyperactive-impulsive symptoms (both p<0.01). Cohen’s d effect size for inattentive symptoms was large at 0.78 at week 8 and 0.84 at week 24 (post-boosters). Further analysis showed that the change in the EEG based BCI ADHD severity measure correlated with the change ADHD Rating Scale scores. The BCI-based attention training game system is a potential new treatment for ADHD.</p> <h3>Trial Registration</h3><p>ClinicalTrials.gov <a href="http://clinicaltrials.gov/ct2/show/NCT01344044">NCT01344044</a></p> </div

Choon Guan Lim (131422)

Tih Shih Lee (131426)

Cuntai Guan (131430)

Daniel Shuen Sheng Fung (131433)

Yudong Zhao (131437)

Stephanie Sze Wei Teng (131441)

Haihong Zhang (131443)

K. Ranga Rama Krishnan (131446)

The Francis Crick Institute

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http://scholarbank.nus.edu.sg/bitstream/10635/109886/1/2012-brain-computer_interface_based_attention_training-published.pdf

A Brain-Computer Interface Based Attention Training Program for Treating Attention Deficit Hyperactivity Disorder

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